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Anti-TNFRSF1B / TNFR2 Antibody (Biotin) LS-C18362

Ordering

Wt. Vol. Conc. Price
50 µg - - $635
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Mouse Monoclonal (IgG1) to Human TNFRSF1B / TNFR2
Human, Monkey
IHC - Frozen, Western blot, Immunoprecipitation, Flow Cytometry
Biotin Conjugated

Details

Human TNFRSF1B / TNFR2
Mouse
Human, Monkey (tested or 100% immunogen sequence identity)
IgG1 Monoclonal
Biotin
Purified
Unmodified

Applications

  • IHC - Frozen
  • Western blot (1:10)
  • Immunoprecipitation
  • Flow Cytometry (1:10)

Specificity and Use

Reacts with the extracellular part of the TNF-RII. It also reacts with the soluble receptor. Cross-reacts with rhesus and cynomolgus natural TNF-RII.
The antibody is an agonistic antibody (after cross-linking) and receptor modulating antibody useful for cell culture experiments, Flow Cytometry and Immunohistology on frozen sections. Furthermore the antibody is useful for Immunoprecipitation, Western Blot and immunoassays. The reactivity of the antibody with cell-bound TNF-Receptor is minimally inhibited by high concentrations of TNF-alpha. Immunohistology: 1:10. Flow Cytometry: 1:10. Western Blot: 1:10. Positive control: Advised positive controls for frozen sections are human lymph nodes and for flow cytometry PHA activated T cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS, 0.02% sodium azide, 0.1% BSA.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About TNFRSF1B / TNFR2

P20333 NM_001066 NP_001057.1

TNFRSF1B Antibody, CD120b antigen Antibody, CD120b Antibody, Etanercept Antibody, p75 TNF receptor Antibody, Soluble TNFR1B variant 1 Antibody, TNFBR Antibody, Tumor necrosis factor receptor Antibody, TNF-R-II Antibody, TNF-R75 Antibody, TNFR2 Antibody, p75TNFR Antibody, p80 TNF-alpha receptor Antibody, TBPII Antibody, TNF-R2 Antibody, TNFR80 Antibody, TNF-RII Antibody, TNFR-II Antibody, TNFR1B Antibody

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Requested From: United States
Date Requested: 12/3/2016

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