Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone HM104] (IgG2a) to Mouse TNFRSF1A / TNFR1
Mouse TNFRSF1A / TNFR1
Mouse (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [HM104]
Flow Cytometry (1 µg/10E6 cells)
Specificity and Use
reacts with the extracellular part of the mouse TNF-Receptor (p55) and with the soluble eceptor. TNF-Receptor (p55) is present on most cell types and is considered to play a prominent roll in cell stimulation by TNF?. Induction of cytotoxicity and other functions are mediated largely via TNF-Receptor p55
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
TNFRSF1A / TNFR1 is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.