Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 4.12] (IgG2a) to Human TNFRSF1A / TNFR1
IHC - Frozen, Flow Cytometry, Cytotoxic Assay
Human TNFRSF1A / TNFR1
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal [4.12]
IHC - Frozen
IHC - Paraffin
Specificity and Use
TNFRSF1A / TNFR1 antibody was raised against tumor Necrosis Factor Receptor.
Recognizes the 60kD TNF-receptor on human cells as well as its soluble fragment and completely neutralizes the whole range of TNF effects.
Suitable for use in Flow Cytometry, Immunohistochemistry, neutralizes TNF-induced cytotoxicity on 4937 MCF-7, HeLA, and L929 cells; TNF-induced MHC expression is inhibited on K562 and Colo 205 cells; TNF induced IL-2R expression is inhibited on Yt cells. Immunohistochemistry: 1:150 (cryostat sections).
PBS, stabilizer and a preservative
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
TNFRSF1A / TNFR1 is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.