Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse, Human, Monkey, Rat, Bovine, Dog, Hamster, Pig, Rabbit, Sheep, Xenopus, Drosophila, Yeast (tested or 100% immunogen sequence identity)
Western blot (1:1000)
Immunoprecipitation (12.5 µg/ml)
Specificity and Use
A synthetic peptide, corresponding to aa29-43 of mouse TNF-R1 (KLH).
Detects an ~55kD protein, corresponding to the apparent molecular mass of TNF-R1 on SDS-PAGE immunoblots. Species cross-reactivity: human, mouse, rat, hamster, bovine, rabbit, monkey, sheep, canine, porcine, Drosophila, Xenopus and yeast. Antibody specificity is confirmed by peptide inhibition studies on immunoblots.
Suitable for use in ELISA, Western Blot and Immunoprecipitation. Western Blot: 1:1000 using ECL. Immunoprecipitation: 12.5 ug/ml. Positive control: Rat Brain Tissue Extract.
PBS, 0.09% sodium azide, 50% glycerol.
Long term: -20°C; Short term: +4°C; Avoid freeze-thaw cycles.
TNFRSF1A / TNFR1 is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor.