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TNFRSF14 / CD270 / HVEM
tumor necrosis factor receptor superfamily, member 14
HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes). Binding by HVEM of the ligand LIGHT induces receptor down regulation. Degradation or release of LIGHT by matrix metalloproteinases then contributes to the return to baseline levels for both LIGHT and HVEM. Soluble HVEM, which tends to form disulfide-linked heterodimeric complexes in solution, can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.
| Gene Name: | tumor necrosis factor receptor superfamily, member 14 |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF14, CD270, CD270 antigen, CD40-like protein, Herpesvirus entry mediator, Herpesvirus entry mediator A, HVEM, LIGHTR, Herpes virus entry mediator A, TR2, ATAR, HVEA |
| Target Sequences: | NM_003820 NP_003811.2 Q92956 |
Publications (3)
1
Polymorphic variants of LIGHT (TNF superfamily-14) alter receptor avidity and bioavailability. Cheung TC, Coppieters K, Sanjo H, Oborne LM, Norris PS, Coddington A, Granger SW, Elewaut D, Ware CF. Journal of immunology (Baltimore, Md. : 1950). 2010 185:1949-58.
[PubMed:20592286]
[PMC:PMC2921593]
Related Antibodies: LS-C41150.
2
B and T lymphocyte attenuator mediates inhibition of tumor-reactive CD8+ T cells in patients after allogeneic stem cell transplantation. Hobo W, Norde WJ, Schaap N, Fredrix H, Maas F, Schellens K, Falkenburg JH, Korman AJ, Olive D, van der Voort R, Dolstra H. Journal of immunology (Baltimore, Md. : 1950). 2012 189:39-49.
[PubMed:22634623]
Related Antibodies: LS-C41150.
3
Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer. Ramsay AG, Clear AJ, Fatah R, Gribben JG. Blood. 2012 120:1412-21. (WB; Human)
[Full Text Article]
[PubMed:22547582]
[PMC:PMC3423779]
Related Antibodies: LS-C41150.
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(104)
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(69)
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(21)
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(51)
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(103)
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(15)
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(4)
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(13)
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(4)
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal Antibody
Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TNFRSF14 / CD270 / HVEM Mouse anti-Human Monoclonal (Azide-free) (ANC3B7) Antibody
Human
ELISA, Flo, IHC, IHC-P
Unconjugated, Azide-free
50 µg/$460
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
Cancer
TNFRSF14 / CD270 / HVEM Mouse anti-Human Monoclonal (2G6-2C7) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal (aa210-236) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
TNFRSF14 / CD270 / HVEM Mouse anti-Human Monoclonal (122) Antibody
Human
ELISA, Flo, WB
Unconjugated
100 µg/$344
Cancer
TNFRSF14 / CD270 / HVEM Goat anti-Human Polyclonal (200-280 aa, Internal) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$485
Sandwich
96-Well Microplate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal (aa210-236) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal (aa210-236) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal (aa210-236) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal (aa210-236) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Monoclonal (Preservative Free) (028) Antibody
Human
ELISA, ICC, IF
Unconjugated, Preservative Free
100 µl/$412
TNFRSF14 / CD270 / HVEM Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo
Unconjugated
100 µg/$626
TNFRSF14 / CD270 / HVEM Rat anti-Human Monoclonal (Laury-1 ) Antibody
Human
Flo, IP
Unconjugated
50 µg/$593
TNFRSF14 / CD270 / HVEM Mouse anti-Human Monoclonal (FITC) (ANC3B7) Antibody
Human
ELISA, Flo
FITC Conjugated
120 Tests/$536
TNFRSF14 / CD270 / HVEM Mouse anti-Human Monoclonal (RPE) (ANC3B7) Antibody
Human
ELISA, Flo
RPE Conjugated
120 Tests/$561
TNFRSF14 / CD270 / HVEM Rabbit anti-Mouse Polyclonal (aa45-262) Antibody
Mouse
WB
Unconjugated
100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571; 2 ml/$777; 5 ml/$1,261
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Monoclonal (Preservative Free) (004) Antibody
Human
Flo
Unconjugated, Preservative Free
100 µl/$412
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Polyclonal (aa118-167) Antibody
Human
WB
Unconjugated
100 µl/$424
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Monoclonal (PE) (004) Antibody
Human
Flo
PE Conjugated
25 Tests/$278; 100 Tests/$421
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Monoclonal (FITC) (004) Antibody
Human
Flo
FITC Conjugated
25 Tests/$263; 100 Tests/$376
TNFRSF14 / CD270 / HVEM Rabbit anti-Human Monoclonal (APC) (004) Antibody
Human
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$421
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