Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes).
Formalin-fixed and paraffin-embedded human lung carcinoma reacted with TNFRSF14 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of anti-TNFRSF14 Antibody antibody pre-incubated without(lane 1) and with(lane 2) blocking peptide in HL-60 cell line lysate. TNFRSF14 (arrow) was detected using the purified antibody.
TNFRSF14 Antibody flow cytometry of HL-60 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.