Human TNFRSF12A / TWEAK Receptor

Mouse

Human (tested or 100% immunogen sequence identity)

IgG2b Monoclonal

ITEM-4

R. Phycoerythrin. Also available Unconjugated.

Protein G purified

Unmodified

Human CD266 transfected P815 cells.

Recognizes human CD266, otherwise known as Fn14/TWEAK Receptor, a 14kD type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors. The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumor cell lines is mediated by CD266, see for details. Clone ITEM-4 is cross-reactive with mouse CD266, and also with Rat-1 cells in flow cytometry.

• Flow Cytometry
• Applications tested for the base form of this product only

The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

PBS, 0.09% Sodium Azide, 5% Sucrose, 1% BSA

Reconstitute with distilled water.

Store at 4°C. Do not freeze. Store undiluted. Protect from light. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: Q9NP84 NCBI: NM_016639 NP_057723.1