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TNFRSF10B / Killer / DR5
tumor necrosis factor receptor superfamily, member 10b
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB.
| Gene Name: | tumor necrosis factor receptor superfamily, member 10b |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9 |
| Target Sequences: | NM_147187 Q6FH58 O14763 |
Publications (3)
1
Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199. Beatrice T Wang, Tasnim Kothambawala #, Ling Wang #, Thomas J Matthew #, Susan E Calhoun, Avneesh K Saini, Maya F Kotturi, Genevive Hernandez, Eric W Humke, Marvin S Peterson, Angus M Sinclair, Bruce A Keyt. The Breast : official journal of the European Society of Mastology. 2021 Dec;;20:2483-2494. [Full Text Article]
[PubMed:34711645]
Related Antibodies: LS-C340229.
2
Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Shi J, Tricot GJ, Garg TK, Malaviarachchi PA, Szmania SM, Kellum RE, Storrie B, Mulder A, Shaughnessy JD, Barlogie B, van Rhee F. Blood. 2008 111:1309-17.
[PubMed:17947507]
[PMC:PMC2214736]
Related Antibodies: LS-C40990.
3
Bortezomib and depsipeptide sensitize tumors to tumor necrosis factor-related apoptosis-inducing ligand: a novel method to potentiate natural killer cell tumor cytotoxicity. Lundqvist A, Abrams SI, Schrump DS, Alvarez G, Suffredini D, Berg M, Childs R. Cancer research. 2006 66:7317-25.
[PubMed:16849582]
Related Antibodies: LS-C40991.
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TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (HS201) Antibody
Human
Flo, Func, ICC, IHC, IHC-P, IP
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (aa388-407) Antibody
Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (OTI1B9) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI1B9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (HS201) Antibody
Human
Flo, Func, ICC, IHC, IHC-P, IP
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Extracellular Domain) (DJR2-2 (2-6)) Antibody
Human
Flo
Unconjugated
100 µg/$344
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal Antibody
Mouse, Human
ICC, WB
Unconjugated
100 µl/$391
TNFRSF10B / Killer / DR5 Rabbit anti-Mouse Polyclonal Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Extracellular Domain) (DJR2-4 (7-8)) Antibody
Human
Flo
Unconjugated
100 µg/$344
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (TR2.21) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
100 µg/$470
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Extracellular Domain) (PE) (DR5-01-1) Antibody
Human
Flo
PE Conjugated
0.1 mg/$435
TNFRSF10B / Killer / DR5 Rabbit anti-Mouse Polyclonal (aa54-180) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$392; 200 µl/$470; 500 µl/$798; 1 ml/$951; 2 ml/$1,211; 5 ml/$2,269
TNFRSF10B / Killer / DR5 Goat anti-Human Polyclonal (Extracellular Domain) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$556
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (aa417-436) (Azide-free) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free
100 µg/$386
E. coli
6His, N-terminus
15.6 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (OTI4B12) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI4B12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (OTI2A5) Antibody
Mouse, Human, Monkey
IHC, WB
Unconjugated
100 µl/$434
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (aa203-411) (Carrier-free) (OTI2A5) Antibody
Mouse, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (Biotin) (HS201) Antibody
Human
Flo, Func, ICC, IP
Biotin Conjugated
100 µg/$491
TNFRSF10B / Killer / DR5 Rabbit anti-Human Polyclonal (aa234-435) Antibody
Human
ICC, IP, WB
Unconjugated
100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136
TNFRSF10B / Killer / DR5 Mouse anti-Human Monoclonal (DJR2-4) Antibody
Human
Flo, IF
Unconjugated
25 µg/$276
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product results
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