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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TNFRSF10B / Killer / DR5 Antibody (Extracellular Domain, clone DR5‑01‑1) LS‑C46124
Antibody
DR5 antibody LS-C46124 is an unconjugated mouse monoclonal antibody to human DR5 (TNFRSF10B / Killer). Validated for Flow.
Catalog
Size
Price
LS-C46124-100
100 µg
Unavailable

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Product Description

DR5 antibody LS-C46124 is an unconjugated mouse monoclonal antibody to human DR5 (TNFRSF10B / Killer). Validated for Flow.
About TNFRSF10B / Killer / DR5
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently. O14763 NM_147187 Q6FH58

TNFRSF10B Antibody, Cytotoxic TRAIL receptor-2 Antibody, CD262 antigen Antibody, DR5 Antibody, Death receptor 5 Antibody, KILLER Antibody, TRAIL-R2 Antibody, TRICK2B Antibody, TRAILR2 Antibody, TRICK2A Antibody, TRICKB Antibody, TRICK2 Antibody, CD262 Antibody, Fas-like protein Antibody, TRAIL receptor 2 Antibody, ZTNFR9 Antibody


Specifications

Target
Human TNFRSF10B / Killer / DR5
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [DR5-01-1]
Conjugations
Unconjugated. Also available conjugated with FITC, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Flow Cytometry (1 - 10 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
Epitope
Extracellular Domain
Specificity
Recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L)
Usage
Flow Cytometry: Recommended dilution - 1-10 ug/ml. Positive control - JURKAT human peripheral blood leukemia T cell line.
Presentation
PBS, 15 mM sodium azide, approx., pH 7.4.
Storage
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/17/2018

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