Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone V1q] (IgD) to Mouse TNF Alpha
Flow Cytometry, Functional Assay
Mouse Monoclonal (IgG1) to Pig TNF Alpha
Western blot, ELISA, Functional Assay
Pig TNF Alpha
Pig (tested or 100% immunogen sequence identity)
Protein A purified
Specificity and Use
TNF Alpha antibody was raised against recombinant porcine TNF alpha.
Specific for porcine tumor necrosis factor- alpha (TNF alpha). Recognizes both native and recombinant TNF alpha. TNF alpha is expressed by a range of cells including macrophages and monocytes, and is an important mediator of the porcine inflammatory response. Clone 6E10 is reported to neutralize the effects of porcine TNF alpha in in vitro cytotoxicity assays using WEHI 164 clone 13 murine fibrosarcoma cells.
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
TNF Alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.