Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Mouse, Rat, Bovine, Dog (at least 90% immunogen sequence identity)
IHC - Paraffin (10 µg/ml)
Specificity and Use
TNC / Tenascin C antibody was raised against recombinant fragment corresponding to a region within amino acids 1925 and 2201 of Tenascin-C (SwissProt P24821). Percent identity by BLAST analysis: Human (100%); Dog (95%); Mouse (92%); Porcine, Rat (91%); Bovine (90%); Chicken (84%).
Human TNC / Tenascin C
Tested in Western blot with the recombinant protein used as the immunogen. Does not detect endogenous Tenascin in Western blot.
PBS, pH 7, 1% BSA, 20% Glycerol, 0.01% Thimerosal
Aliquot and freeze at -20° C. Avoid freeze-thaw cycles.
Tenascin C (TNC) is the founding member of the gene family. In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and cartilage. The basic structure is 14 EGF-like repeats towards the N-terminal end, and 8 or more fibronectin-III domains which vary upon species and variant. TNC has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium.