Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Protein G purified
Specificity and Use
TLR4 antibody was raised against ba/F3 cell line expressing human TLR4 cell surface antigen, consisting of 799 amino acids. Molecular weight: 88kD.
Recognizes human TLR4 (Toll Like Receptor 4).
Suitable for use in Immunoprecipitation, Neutralization, Flow Cytometry and Confocal Microscopy. Flow Cytometry: 2-5 ug/1 x 1E6 cells. Positive control: ThP1 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.02% sodium azide.
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific.