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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TLR4 Antibody (PE) LS‑C10718
TLR4 antibody LS-C10718 is a PE-conjugated mouse monoclonal antibody to human TLR4. Validated for Flow, IP and Neut.
Antibody
Catalog
Size
Price
LS-C10718-100
100 µg
$725

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Product Description

TLR4 antibody LS-C10718 is a PE-conjugated mouse monoclonal antibody to human TLR4. Validated for Flow, IP and Neut.
About TLR4
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific. O00206 NM_138554 O00206

TLR4 Antibody, CD284 Antibody, CD284 antigen Antibody, Homolog of Drosophila toll Antibody, TLR-4 Antibody, TOLL Antibody, ARMD10 Antibody, Toll-like receptor 4 Antibody, HToll Antibody


Specifications

Target
Human TLR4
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a,k Monoclonal
Conjugations
Phycoerythrin
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Immunoprecipitation
  • Flow Cytometry
  • Neutralization
Immunogen
TLR4 antibody was raised against ba/F3 cell line expressing human TLR4 cell surface antigen, consisting of 799 amino acids. Molecular weight: 88kD.
Specificity
Recognizes human TLR4 (Toll Like Receptor 4).
Usage
Suitable for use in Immunoprecipitation, Neutralization, Flow Cytometry and Confocal Microscopy. Flow Cytometry: 2-5 ug/1 x 1E6 cells. Positive control: ThP1 cells. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Presentation
PBS, 0.02% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/16/2018

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