Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
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Reacts with the Toll-like receptor 4 (TLR4, CD284). Reacts preferentially, especially in Flow Cytometry, with mouse TLR4 that is associated with MD-2. This antibody is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to coprecipitate MD-2 (30kD) with TLR4 (100kD). The antibody recognizes the mouse TLR4/MD-2 complex and is not useful for detection of TLR4 (CD284) alone.
Can be used for Flow Cytometry, Immunoprecipitation and Immunohistology on frozen sections. The antibody recognizes the mouse TLR4/MD-2 complex and is not useful for detection of TLR4 (CD284) alone. Immunohistology: 1:50. Flow Cytometry: 1:50.
Packaging
PBS, 0.02% sodium azide, 0.1% BSA.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
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