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Anti-TLR4 Antibody (C-Terminus) LS-C10730

Ordering

Wt. Vol. Conc. Price
100 µg - - $530
Inquire for larger quantities

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Rabbit Polyclonal to Human TLR4
Human
Western blot, ELISA
Unconjugated

Details

Human TLR4
Rabbit
Human (tested or 100% immunogen sequence identity)
Polyclonal
Immunoaffinity purified

Applications

Western blot (1 - 3 µg/ml), ELISA (0.1 - 1 µg/ml)

Specificity and Use

TLR4 antibody was raised against synthetic peptide derived from the carboxyl termini of various human TLR4 (Toll-like receptor 4) isoforms A-D.
C-Terminus
This antibody, specific for human TLR4, shows a positive result for ELISA and detects 2-3 protein species of ~70 to ~100kD on Western blot analysis using human placenta tissue homogenate, JEG-3 placenta choriocarcinoma, U-937 histocytic lymphoma, BC-1 human B-lymphocyte lymphoma, Nalm-6-pre-B lymphocyte and REH pre-B lymphocyte cell lysates. Reactivity has been confirmed with human placenta tissue homogenate, JEG-3 placenta choriocarcinoma, U-937 histocytic lymphoma, BC-1 human B-lymphocyte lymphoma, Nalm-6-pre-B lymphocyte and REH pre-B lymphocyte cell lysates. This antibody should be theoretically reactive to gorilla, orangutan and chimpanzee TRL4 due to amino acid homology.
Suitable for use in ELISA and Western Blot. ELISA: 0.1-1 ug/ml. Western Blot: 1-3 ug/ml.

Packaging

PBS, pH 7.4, 0.1% sodium azide.
Long term: Add glycerol (40-50%) -20°C; Short term: +4°C
For research use only.

About TLR4

O00206 NM_138554 O00206

TLR4 Antibody, CD284 Antibody, CD284 antigen Antibody, Homolog of Drosophila toll Antibody, TLR-4 Antibody, TOLL Antibody, ARMD10 Antibody, Toll-like receptor 4 Antibody, HToll Antibody

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni2+. Responses triggered by Ni2+ require non-conserved histidines and are, therefore, species-specific.

Requested From: United States
Date Requested: 9/29/2016

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