Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Western blot (1:10)
Flow Cytometry (1:10)
Specificity and Use
Recognizes human TLR3 (CD283).
Can be used for intracellular Flow Cytometry and Western Blot. Furthermore the antibody is useful for in vitro inhibition by the ligand poly (I): poly (C). Flow Cytometry: 1:10. Western Blot: 1:10. For inhibition studies dilutions have to be made according to the amounts ligand to be inactivated.
PBS, 0.1% BSA.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.