Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
TLR3 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
Mouse spleen cells stained with Rat anti-Mouse CD8 alpha:APC and (A) Rat anti-Mouse CD283 or (B) rat IgG control. Detection with Goat anti-Rat IgG:Dylight488 was performed following permeabilization of the cells with Leucoperm prior to incubation with Rat anti-Mouse CD283. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Mouse spleen cells stained with Rat anti-Mouse CD8 alpha:APC and (A) Rat anti-Mouse CD283:FITC or (B) rat IgG control. Staining was performed following permeabilization of the cells with Leucoperm and incubation with Mouse sero block FCR. This image was taken for the unconjugated form of this product. Other forms have not been tested.