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Tlr11
toll-like receptor 11
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptibility to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.
| Gene Name: | toll-like receptor 11 |
| Family/Subfamily: | Toll-like Receptor |
| Synonyms: | Tlr11, Gm287, Toll-like receptor 11 |
| Target Sequences: | NM_205819 NP_991388.2 Q6R5P0 |
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