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TLK1
tousled-like kinase 1
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
| Gene Name: | tousled-like kinase 1 |
| Family/Subfamily: | Protein Kinase , TLK |
| Synonyms: | TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK |
| Target Sequences: | NM_012290 NP_036422.3 Q9UKI8 |
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TLK1 Rabbit anti-Human Polyclonal (aa730-779) Antibody
Mouse, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
TLK1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ICC, IF, IP, WB
Unconjugated, Preservative Free
100 µl/$412
![TLK1 Antibody - Immunoperoxidase of monoclonal antibody to TLK1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 1 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/tlk1-antibody-clone-4b3-ls-c133607/52274_5189030.jpg)
TLK1 Mouse anti-Human Monoclonal (4B3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
TLK1 Rabbit anti-Human Polyclonal (aa720-750) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
TLK1 Rabbit anti-Human Polyclonal (aa720-750) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
TLK1 Rabbit anti-Human Polyclonal (aa720-750) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
TLK1 Rabbit anti-Human Polyclonal (aa720-750) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
TLK1 Rabbit anti-Human Polyclonal (aa720-750) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TLK1 Rabbit anti-Human Polyclonal (aa720-750) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
TLK1 Rabbit anti-Human Polyclonal (aa720-750) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
TLK1 Rabbit anti-Human Polyclonal (680-760 aa) Antibody
Mouse, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TLK1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF
Unconjugated
100 µg/$357
TLK1 Rabbit anti-Mouse Polyclonal (aa701-728) Antibody
Mouse
ELISA, WB
Unconjugated
200 µl/$734
TLK1 Rabbit anti-Mouse Polyclonal (aa701-728) (Biotin) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
TLK1 Rabbit anti-Mouse Polyclonal (aa701-728) (FITC) Antibody
Mouse
ELISA, WB
FITC Conjugated
200 µl/$952
TLK1 Rabbit anti-Mouse Polyclonal (aa701-728) (APC) Antibody
Mouse
ELISA, WB
APC Conjugated
200 µl/$952
TLK1 Rabbit anti-Mouse Polyclonal (aa701-728) (PE) Antibody
Mouse
ELISA, WB
PE Conjugated
200 µl/$952
TLK1 Rabbit anti-Mouse Polyclonal (aa701-728) (Azide-free) (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
TLK1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
100 µl/$389; 200 µl/$503
TLK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
TLK1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
![TLK1 Antibody - Anti-Tlk-1 Antibody - Western Blot. Western blot of Affinity Purified anti-Tlk-1 antibody shows detection of a band ~64 kD corresponding to isoform 3 of human Tlk-1 (arrowhead). Specific reactivity with this band is blocked when the antibody is pre-incubated with the immunizing peptide (data not shown). Approximately 30 ug of a HeLa nuclear extract was separated by SDS-PAGE and transferred onto nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:250 for 2h at room temperature followed by washes and reaction with a 1:10000 dilution of IRDye 800 conjugated Gt-a-Rabbit IgG [H&L] MX ( for 45 min at room temperature. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.](https://lsbio-7d62.kxcdn.com/image2/tlk1-antibody-aa730-755-ls-c18924/62845_5215849.jpg)
TLK1 Rabbit anti-Human Polyclonal (aa730-755) Antibody
Dog, Human, Chimpanzee, Orangutan
ELISA, WB
Unconjugated
100 µg/$567
TLK1 Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TLK1 Rabbit anti-Human Polyclonal (aa201-250) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TLK1 Rabbit anti-Human Polyclonal (aa150-200) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
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