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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TLE1 / TLE 1 Antibody (aa181‑198) LS‑C7308
TLE 1 antibody LS-C7308 is an unconjugated rabbit polyclonal antibody to TLE 1 (TLE1) from human, bovine, horse and other species. Validated for ELISA, IHC and WB.
Antibody
Catalog
Size
Price
LS-C7308-50
50 µg (1 mg/ml)
$375

Popular TLE1 / TLE 1 Products

IHC of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-TLE1 mouse monoclonal antibody.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
IHC of TLE1 on FFPE Synovial Sarcoma tissue.
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IHC of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TLE1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
IHC of paraffin-embedded Human pancreas tissue using anti-TLE1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Human Uterus: Formalin-Fixed, Paraffin-Embedded (FFPE)
Species: Human, Mouse, Rat, Bovine, Guinea pig, Horse, Pig
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Immunoprecipitation

Product Description

TLE 1 antibody LS-C7308 is an unconjugated rabbit polyclonal antibody to TLE 1 (TLE1) from human, bovine, horse and other species. Validated for ELISA, IHC and WB.
About TLE1 / TLE 1
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. Q04724 NM_005077 NP_005068.2

TLE1 Antibody, E(Sp1) homolog Antibody, ESG Antibody, GRG1 Antibody, Enhancer of split groucho 1 Antibody, ESG1 Antibody


Specifications

Target
Human TLE1 / TLE 1
Host
Rabbit
Reactivity
Human, Monkey, Bovine, Horse, Pig (tested or 100% immunogen sequence identity)
Predicted
Mouse, Rat, Bat, Dog (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Affinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Frozen (1:200 - 1:1000)
  • Western blot (1:200 - 1:1000)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
TLE1 / TLE 1 antibody was raised against synthetic peptide, DDKKHHDAEHHRDREPGT, amino acids 181-198 from human Groucho 1 (TLE1) conjugated to BSA. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Elephant, Bovine, Horse, Pig (100%); Mouse, Rat, Dog, Bat, Opossum (94%); Rabbit, Xenopus (89%).
Epitope
aa181-198
Specificity
Recognizes Groucho 1/TLE1/ESG1 transcription factor (Mr 83.5kD). Species cross-reactivity: Human and rodent.
Usage
Suitable for use in ELISA, Western Blot and Immunohistochemistry. Western Blot: 1:200-1:1000 (ECL). Immunohistochemistry: 1:200-1:1000. Frozen sections. Not tested for paraffin.
Presentation
PBS, pH 7.2, 40% Glycerol, No preservatives added
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: United States
Date Requested: 8/16/2018

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