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TIP120 / CAND1
cullin-associated and neddylation-dissociated 1
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes.
| Gene Name: | cullin-associated and neddylation-dissociated 1 |
| Synonyms: | CAND1, KIAA0829, TBP interacting protein, TBP-interacting protein 120A, TIP120, p120 CAND1, TIP120A |
| Target Sequences: | NM_018448 NP_060918.2 Q86VP6 |
Publications (3)
1
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases. Liu J, Furukawa M, Matsumoto T, Xiong Y. Molecular cell. 2002 10:1511-8.
[PubMed:12504025]
Related Antibodies: LS-B347.
2
AtCAND1, a HEAT-repeat protein that participates in auxin signaling in Arabidopsis. Cheng Y, Dai X, Zhao Y. Plant physiology. 2004 135:1020-6.
[PubMed:15181201]
[PMC:PMC514136]
Related Antibodies: LS-B347.
3
Arabidopsis CAND1, an unmodified CUL1-interacting protein, is involved in multiple developmental pathways controlled by ubiquitin/proteasome-mediated protein Degradation. Feng S, Shen Y, Sullivan JA, Rubio V, Xiong Y, Sun TP, Deng XW. The Plant cell. 2004 16:1870-82.
[PubMed:15208391]
[PMC:PMC514167]
Related Antibodies: LS-B347.
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TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa11-24) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa1180-1230) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
![TIP120 / CAND1 Antibody - Immunoperoxidase of monoclonal antibody to CAND1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml]](https://lsbio-7d62.kxcdn.com/image2/tip120-cand1-antibody-clone-5d7-ls-c133780/52929_5043981.jpg)
TIP120 / CAND1 Mouse anti-Human Monoclonal (5D7) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
100 µg/$423
TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa112-161) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa112-161) (HRP) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
HRP Conjugated
100 µl/$442
TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa112-161) (Biotin) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
Biotin Conjugated
100 µl/$442
TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa112-161) (FITC) Antibody
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
WB
FITC Conjugated
100 µl/$442
TIP120 / CAND1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TIP120 / CAND1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TIP120 / CAND1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TIP120 / CAND1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TIP120 / CAND1 Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Mouse, Rat, Human
ICC, IF, IHC-P
Unconjugated, Preservative Free
100 µl/$412
TIP120 / CAND1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TIP120 / CAND1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 100 µl/$389
TIP120 / CAND1 Rabbit anti-Human Polyclonal (aa600-650) Antibody
Human
IP
Unconjugated
10 µg/$295; 100 µl/$514
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
136.2 kDa
100 µg/$494
293T Cells
Myc-DDK (Flag)
136.2 kDa
20 µg/$150
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