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Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Plays a role in shelterin complex assembly. Isoform 1 may have additional role in tethering telomeres to the nuclear matrix.
Gene Name: | TERF1 (TRF1)-interacting nuclear factor 2 |
Synonyms: | TINF2, DKCA3, TIN2 |
Target Sequences: | NM_012461 NP_036593.2 Q9BSI4 |
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