Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(tested or 100% immunogen sequence identity)
Protein G purified
TIMP2 antibody was raised against native human pro-MMP-2/TIMP-2.
Recognizes a protein of 21kD, identified as tissue inhibitor of metalloproteinases-2 (TIMP-2) and also reacts with the MMP-2/TIMP-2 complex. Reacts with human, does not react with mouse and rat.
ELISA (For coating, order without BSA). Immunoprecipitation (Use Protein G). (Ab 2 ug/mg protein lysate). Western Blot (Ab 1 ug/ml for 2hrs at RT). Cellular Localization: Cytoplasmic. Positive control: HFL-1 cells. Conditioned, serum-free medium from (TPA-treated) human fetal lung cells. Bladder, breast, and ovarian carcinomas.
PBS, pH 7.4, 0.09% Sodium Azide, 0.2% BSA
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
TIMP2 is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells.