Human TIMP1

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Protein A purified

Unmodified

Human tissue inhibitor of metalloproteinase 1 (TIMP-1).

Recognizes human Tissue inhibitor of metalloproteinases 1, also known as TIMP-1, Metalloproteinase inhibitor 1, Erythroid-potentiating activity or Fibroblast collagenase inhibitor. TIMP-1 is a 207 amino acid, ~23 kD secreted glycoprotein containing a 23 amino acid signaling peptide and a single domain. TIMP-1 is a metalloproteinase inhibitor that functions by formation of complexes with target metalloproteinases, binding to their catalytic cofactor leading to irreversible inactivation of the target metalloproteinase. TIMP-1 also functions as a growth factor and activates signalling cascades via CD63 and CD29. In humans TIMP-1 also functions to promote growth and differentiation of erythroid progenitors. Recognizes both native and denatured TIMP-1, as well as TIMP-1 in and out of enzyme/inhibitor complex. Is not known to be neutralizing. TIMP-1 is expressed by a wide range of cells including microvascular endothelial cells, smooth muscle cells, mesangial cells and some fibroblasts. Has been used successfully for the localization of TIMP-1 in a rabbit model of hypertrophic scarring by immunohistochemistry on formalin fixed, paraffin embedded sections.

• IHC
• IHC - Paraffin (1 - 5 µg/ml)
• Western blot (5 - 10 µg/ml)
• ELISA (2.5 - 10 µg/ml)

PBS, 0.02% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P01033 NCBI: NM_003254 NP_003245.1