TIMELESS

timeless circadian clock

Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK|NPAS2-ARTNL/BMAL1|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.

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Products

Antibodies (25)

Proteins (4)

ELISA Kits (1)

Type

Over-Expression Lysate (2)

Primary (25)

Recombinant (2)

Sandwich (1)

Target

TIMELESS (30)

Reactivity

Human (25)

Mouse (8)

Rat (7)

Bat (3)

Bovine (6)

Chimpanzee (9)

Dog (6)

Drosophila (3)

Gibbon (6)

Guinea pig (6)

Horse (9)

Monkey (3)

Pig (6)

Rabbit (6)

Sheep (6)

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Application

IHC (7)

IHC-P (5)

WB (19)

Flo (1)

ELISA (5)

ICC (1)

IP (3)

Peptide-ELISA (1)

Host

rabbit (24)

rat (1)

Product Group

IHCPlus (1)

Isotype

IgG (23)

IgG2a (1)

Clonality

monoclonal mc (1)

polyclonal pc (24)

Clone

RMT2-25 (1)

Format

96-Well Strip Plate (1)

Biotin Conjugated (4)

FITC Conjugated (5)

HRP Conjugated (4)

Unconjugated (12)

Epitope

N-Terminus (7)

C-Terminus (4)

aa290-339 (4)

aa1120-1170 (1)

aa1170-C-term (1)

Publications

No (30)

Sample Type

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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TIMELESS Antibody (aa290-339) LS-B6788

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (aa290-339) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

TIMELESS Antibody (aa290-339, HRP) LS-C430712

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (aa290-339) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

TIMELESS Antibody (aa290-339, Biotin) LS-C430710

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (aa290-339) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

TIMELESS Antibody (aa290-339, FITC) LS-C430711

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (aa290-339) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Rat, Pig, Horse, Chimpanzee, Human

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

TIMELESS Antibody (C-Terminus) LS-C31480

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

TIMELESS Antibody (C-Terminus, HRP) LS-C436938

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Drosophila, Horse, Guinea pig, Sheep, Bovine, Rat, Human, Gibbon, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

TIMELESS Antibody (C-Terminus, Biotin) LS-C436936

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Drosophila, Horse, Guinea pig, Sheep, Bovine, Rat, Human, Gibbon, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

TIMELESS Antibody (C-Terminus, FITC) LS-C436937

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Drosophila, Horse, Guinea pig, Sheep, Bovine, Rat, Human, Gibbon, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

TIMELESS Antibody LS-C661038

Antibody:

TIMELESS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

TIMELESS Antibody (N-Terminus) LS-C145102

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

100 µl/$440; 200 µl/$468

Select

TIMELESS Antibody (aa1170-C-term) LS-C287793

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (aa1170-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

TIMELESS Antibody LS-C673094

Antibody:

TIMELESS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

TIMELESS Antibody (HRP) LS-C673095

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

TIMELESS Antibody (Biotin) LS-C673097

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

TIMELESS Antibody (FITC) LS-C673096

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

TIMELESS Antibody (N-Terminus) LS-C10570

Antibody:

TIMELESS Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$832

Select

TIMELESS Antibody (N-Terminus) LS-C10582

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$801

Select

TIMELESS Antibody LS-C807086

Antibody:

TIMELESS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

TIMELESS Antibody (clone RMT2-25, FITC) LS-C187574

Antibody:

TIMELESS Rat anti-Mouse Monoclonal (FITC) (RMT2-25) Antibody

Reactivity:

Mouse

Applications:

Flo

Format:

FITC Conjugated

Price:

0.1 mg/$435

Select

TIMELESS Antibody (N-Terminus) LS-C31481

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

TIMELESS Antibody (N-Terminus, HRP) LS-C436935

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Rabbit, Dog, Sheep, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

TIMELESS Antibody (N-Terminus, Biotin) LS-C436933

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Rabbit, Dog, Sheep, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

TIMELESS Antibody (N-Terminus, FITC) LS-C436934

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Rabbit, Dog, Sheep, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

TIMELESS Antibody LS-C834230

Antibody:

TIMELESS Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

TIMELESS Antibody (aa1120-1170) LS-C287794

Antibody:

TIMELESS Rabbit anti-Human Polyclonal (aa1120-1170) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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