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Anti-THRA / THR Alpha Antibody (Ligand-binding Domain) IHC-plus™ LS-A6194

Note: This antibody replaces LS-C42456

Ordering

Wt. Vol. Conc. Price
50 µg 50 µl 1 mg/ml $395
Inquire for larger quantities
Same day shipping In Stock - Same day shipping

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
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Most Popular THRA / THR Alpha Antibodies

Anti-THRA / THR Alpha Antibody (Ligand-binding Domain) IHC-plus™ LS-A6196
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-THRA / THR Alpha Antibody (aa325-374) LS-C134993
Rabbit Polyclonal to Rat THRA / THR Alpha
Rat, Human, Monkey, Mouse, Bovine, Dog, Guinea pig, Hamster, Horse, Pig, Rabbit, Sheep, Zebrafish
Western blot
Unconjugated
Western blot Image

100% Guaranteed 100% Guaranteed In Stock In Stock
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC - Paraffin
Unconjugated

Details

Human THRA / THR Alpha
Rabbit
Human, Monkey (tested or 100% immunogen sequence identity)
Mouse, Rat, Bovine, Dog, Hamster, Horse, Pig, Rabbit, Sheep (at least 90% immunogen sequence identity)
Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

IHC - Paraffin (10 - 15 µg/ml)

Specificity and Use

THRA / THR Alpha antibody was raised against synthetic 20 amino acid peptide from ligand-binding domain of human THRA. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Mouse, Rat, Sheep, Dog, Bovine, Hamster, Elephant, Panda, Rabbit, Horse, Pig (95%); Lizard (85%); Opossum (80%).
LS-E29114 - Liquid - 50 µg - $145.00
Ligand-binding Domain
Human THRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Immunohistochemistry: LS-A6194 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-A6194 was determined to be 10 ug/ml.

Packaging

PBS, less than 0.1% sodium azide.
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles.
For research use only.

About THRA / THR Alpha

P10827 NM_003250 NP_003241.2

THRA Antibody, AR7 Antibody, C-ERBA-1 Antibody, C-erbaalpha Antibody, EAR-7.1/EAR-7.2 Antibody, ERB-T-1 Antibody, ERBA1 Antibody, EAR-7 Antibody, ERBA-related 7 Antibody, HTR alpha 1 Antibody, HTR alpha 2 Antibody, THRA1 Antibody, Thyroid hormone receptor alpha Antibody, T3R Antibody, Tralpha2 Antibody, Triiodothyronine receptor Antibody, V-erbA-related protein 7 Antibody, Thyroid hormone receptor Antibody, Tralpha1 Antibody, NR1A1 Antibody, THRA3 Antibody, C-erbA-alpha Antibody, CHNG6 Antibody, EAR7 Antibody, ERBA Antibody, Erba-alpha Antibody, THRA2 Antibody, TR alpha Antibody, Tralpha Antibody

Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410 aa) (Nakai et al. 1988), TR alpha2 (490 aa) ( Nakai et al. 1988), TR deltaalpha1 (~154 aa), and TR deltaalpha2 (~237 aa); however, only TR alpha1 is able to bind the ligand ( Lazar et al. 1988).

Immunohistochemistry

Immunohistochemistry
Anti-THRA antibody LS-A6194 IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
 

Requested From: United States
Date Requested: 12/4/2016

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