Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Polyclonal (IgG) to Human THPO / TPO / Thrombopoietin
IHC, Western blot
Mouse Monoclonal (IgM) to Human THPO / TPO / Thrombopoietin
Western blot, ELISA
Human THPO / TPO / Thrombopoietin
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
Specificity and Use
Recognizes recombinant Thrombopoietin (human) and the reactivity of TPO (14-29) is ~80%. Does not react to recombinant EPO (human), ACTH (1-39), Calcitonin (human), Insulin (human), Insulin-like Growth Factor 1 (human), Insulin-like Growth Factor 2 (human) and Parathyroid hormone (human). By epitope mapping with synthetic peptides, it was found that this antibody binds to residues 14-29 of human TPO.
Suitable for use in ELISA, Western Blot.
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1.