THOC5

THO complex 5

Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes.Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.

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Antibodies (18)

Proteins (1)

Type

Primary (18)

Recombinant (1)

Target

THOC5 (19)

Reactivity

Human (18)

Mouse (6)

Rat (5)

Application

IHC (8)

IHC-P (2)

WB (11)

ELISA (4)

IF (2)

IP (3)

Peptide-ELISA (2)

Host

rabbit (18)

Isotype

IgG (13)

Clonality

polyclonal pc (18)

Format

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

Unconjugated (12)

Epitope

N-Terminus (4)

aa25-75 (2)

530-610 aa, C-terminal (1)

Glu602 (1)

aa300-325 (1)

aa561-610 (1)

Publications

No (19)

Tag

GST (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

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Purified (1)

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THOC5 Antibody LS-C661022

Antibody:

THOC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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THOC5 Antibody LS-C672406

Antibody:

THOC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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THOC5 Antibody (HRP) LS-C672408

Antibody:

THOC5 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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THOC5 Antibody (Biotin) LS-C672409

Antibody:

THOC5 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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THOC5 Antibody (FITC) LS-C672410

Antibody:

THOC5 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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THOC5 Antibody (aa25-75) LS-C288877

Antibody:

THOC5 Rabbit anti-Human Polyclonal (aa25-75) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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THOC5 Antibody (530-610 aa, C-terminal) LS-C383510

Antibody:

THOC5 Rabbit anti-Human Polyclonal (530-610 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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THOC5 Antibody LS-C824735

Antibody:

THOC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

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THOC5 Antibody (Glu602) LS-C193167

Antibody:

THOC5 Rabbit anti-Human Polyclonal (Glu602) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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THOC5 Antibody (aa561-610) LS-C120458

Antibody:

THOC5 Rabbit anti-Human Polyclonal (aa561-610) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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THOC5 Antibody (aa300-325) LS-C288875

Antibody:

THOC5 Rabbit anti-Human Polyclonal (aa300-325) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

THOC5 Antibody LS-C809801

Antibody:

THOC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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THOC5 Antibody (aa25-75) LS-C286774

Antibody:

THOC5 Rabbit anti-Human Polyclonal (aa25-75) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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THOC5 Antibody (N-Terminus) LS-C346013

Antibody:

THOC5 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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THOC5 Antibody (N-Terminus, HRP) LS-C469691

Antibody:

THOC5 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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THOC5 Antibody (N-Terminus, Biotin) LS-C469689

Antibody:

THOC5 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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THOC5 Antibody (N-Terminus, FITC) LS-C469690

Antibody:

THOC5 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

THOC5 Antibody LS-C747046

Antibody:

THOC5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Human THOC5 Protein (Recombinant GST) (Full Length) - LS-G31213

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

104.9 kDa

Price:

10 µg/$479; 25 µg/$670

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