Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1D8] (IgG1) to Human TH / Tyrosine Hydroxylase
IHC - Paraffin, Immunofluorescence, Western blot
Rabbit Polyclonal to Rat TH / Tyrosine Hydroxylase
IHC, Western blot
Rat TH / Tyrosine Hydroxylase
Specificity and Use
TH / Tyrosine Hydroxylase antibody was raised against synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho-Ser31 of rat tyrosine hydroxylase (TH). Rabbit anti-TH (Ser31) was purified by sequential chromatography on phospho- and non-phosphopeptide affinity columns
150 mM sodium chloride, 10 mM HEPES, 100 ug per ml BSA, 50% glycerol, pH 7.5.
Tyrosine hydroxylase in involved in the conversion of phenylalanine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines and as such has a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript. Expression of the mRNAs varies in different parts of the nervous system. Defects in TH are the cause of autosomal recessive Segawa syndrome.