Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rabbit Monoclonal [clone EP1532Y] (IgG) to Human TH / Tyrosine Hydroxylase
Human, Mouse, Rat
IHC - Paraffin, ICC, Western blot, Flow Cytometry
Rabbit Polyclonal to Human TH / Tyrosine Hydroxylase
Human, Mouse, Rat
IHC - Frozen, Immunofluorescence, Western blot, Flow Cytometry
Human TH / Tyrosine Hydroxylase
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Protein G purified
IHC - Frozen
Western blot (1:1000)
Specificity and Use
Synthetic phosphopeptide corresponding to an amino acid sequence within Tyrosine Hydroxylase which includes phosphorylated Ser 31.
Specific for Tyrosine Hydroxylase, when phosphorylated at serine 31. Species cross Reactivity: Human, mouse, rat.
Suitable for use in Flow Cytometry, Western Blot and Immunohistochemistry (frozen). Western Blot:1:1000, detects a band of approximately 60kD in PC-12 cell lysates. Immunofluorescence: 1:1000. Immunohistochemistry: 1:1000.
Tyrosine hydroxylase in involved in the conversion of phenylalanine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines and as such has a key role in the physiology of adrenergic neurons. TH is encoded by four distinct mRNAs produced by alternative splicing of a single primary transcript. Expression of the mRNAs varies in different parts of the nervous system. Defects in TH are the cause of autosomal recessive Segawa syndrome.