TGFBR1 / ALK5

transforming growth factor, beta receptor 1

Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

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Products

Antibodies (51)

ELISA Kits (12)

Proteins (9)

Type

Custom (4)

Over-Expression Lysate (2)

Primary (51)

Recombinant (7)

Sandwich (8)

Target

TGFBR1 / ALK5 (72)

Reactivity

Human (47)

Mouse (34)

Rat (21)

Bat (2)

Bovine (3)

Dog (2)

Guinea pig (1)

Hamster (1)

Horse (1)

Monkey (1)

Pig (3)

Rabbit (2)

Sheep (1)

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Application

IHC (12)

IHC-P (3)

WB (44)

ELISA (23)

ICC (1)

IF (10)

Peptide-ELISA (5)

Host

rabbit (48)

mouse (1)

goat (2)

Product Group

IHCPlus (1)

PathPlus Neuro (1)

Isotype

IgG (33)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (50)

Clone

234R32 (1)

Format

96-Well Strip Plate (12)

APC (1)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Unconjugated (30)

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Epitope

aa162-403 (8)

aa134-163 (7)

aa141-169 (7)

100-180 aa (2)

pSer165 (2)

Glu161 (1)

Internal (1)

aa112-161 (1)

aa131-180 (1)

aa145-172 (1)

aa149-186 (1)

aa50-63 (1)

p165 (1)

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Publications

No (72)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (3)

Plasma (5)

Serum (5)

Tissue Homogenates (5)

Tag

Fc, C-terminus (2)

GST, N-terminus (1)

His-Fc (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (3)

Human (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (4)

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PathPlus™ TGFBR1 / ALK5 Antibody (aa50-63) LS-B9436

Neuroscience

(5.0) Rating

Antibody:

TGFBR1 / ALK5 Goat anti-Human Polyclonal (aa50-63) Antibody

Reactivity:

Rabbit, Mouse, Dog, Bovine, Rat, Horse, Bat, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

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TGFBR1 / ALK5 Antibody (100-180 aa) LS-C381773

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (100-180 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TGFBR1 / ALK5 Antibody (aa131-180) LS-C117992

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa131-180) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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TGFBR1 / ALK5 Antibody (aa134-163) LS-C97221

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Mouse TGFBR1 / ALK5 (Sandwich ELISA) ELISA Kit - LS-F9232

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$782

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IHC-plus™ TGFBR1 / ALK5 Antibody LS-B16845

(4.0) Rating

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$460

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Human TGFBR1 / ALK5 Protein (Recombinant His-GST) (Thr200-Mey503) - LS-G97152

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

62.6 kDa

Price:

50 µg/$707

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Human TGFBR1 / ALK5 (Sandwich ELISA) ELISA Kit - LS-F4042

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Tissue Homogenates

Price:

1 Plate/$764

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Human TGFBR1 / ALK5 (Sandwich ELISA) ELISA Kit - LS-F32342

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

31.2 - 2000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human TGFBR1 / ALK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78778

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.96 kDa

Price:

20 µg/$215

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Human TGFBR1 / ALK5 Protein (Recombinant His-Fc) (Met1-Glu125) - LS-G97943

Source:

HEK 293 Cells

Tag:

His-Fc

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

38.8 kDa

Price:

100 µg/$710

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TGFBR1 / ALK5 Antibody (100-180 aa) LS-C386397

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (100-180 aa) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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TGFBR1 / ALK5 Antibody (p165) LS-C823031

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (p165) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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TGFBR1 / ALK5 Antibody LS-C406059

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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TGFBR1 / ALK5 Antibody LS-C499921

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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TGFBR1 / ALK5 Antibody (FITC) LS-C499925

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• FITC

• Unconjugated
• FITC

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Human TGFBR1 / ALK5 (Sandwich ELISA) ELISA Kit - LS-F38226

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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TGFBR1 / ALK5 Antibody (aa134-163) LS-C328938

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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TGFBR1 / ALK5 Antibody (aa134-163, Biotin) LS-C283697

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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TGFBR1 / ALK5 Antibody (aa134-163, FITC) LS-C283699

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

TGFBR1 / ALK5 Antibody (aa134-163, PE) LS-C283704

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

TGFBR1 / ALK5 Antibody (aa134-163, APC) LS-C283698

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

TGFBR1 / ALK5 Antibody (aa134-163, Azide-free, HRP) LS-C283700

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (aa134-163) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

TGFBR1 / ALK5 Antibody LS-C417166

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

TGFBR1 / ALK5 Antibody (phospho-Ser165) LS-C823030

Antibody:

TGFBR1 / ALK5 Rabbit anti-Human Polyclonal (pSer165) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

100 µg/$357

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