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TGFB1 / TGF Beta 1

transforming growth factor, beta 1

TGFB1 / TGF Beta 1 is a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.

Gene Name: transforming growth factor, beta 1
Family/Subfamily: TGF beta , not assigned-TGF beta
Synonyms: TGFB1, CED, DPD1, Diaphyseal dysplasia 1, LAP, Latency-associated peptide, TGF Beta, TGFbeta, TGF-beta 1 protein, TGF-beta-1, TGFB
Target Sequences: NM_000660 NP_000651.3 P01137

Publications (13)

1
Blockade of KCa3.1 ameliorates renal fibrosis through the TGF-ß1/Smad pathway in diabetic mice. Huang C, Shen S, Ma Q, Chen J, Gill A, Pollock CA, Chen XM. Diabetes. 2013 62:2923-34. (WB; Zebrafish) [Full Text Article] [PubMed:23656889] [PMC:PMC3717839]
2
Bone regeneration in minipigs by intrafibrillarly-mineralized collagen loaded with autologous periodontal ligament stem cells. Zhang C, Yan B, Cui Z, Cui S, Zhang T, Wang X, Liu D, Yang R, Jiang N, Zhou Y, Liu Y. Scientific reports. 2017 September;7:10519. (Pig) [Full Text Article] [PubMed:28874877] [PMC:PMC5585269] Related Antibodies: LS-C10852.
3
Integrin a?ß5 in vitro inhibition limits pro-fibrotic response in cardiac fibroblasts of spontaneously hypertensive rats. Perrucci GL, Barbagallo VA, Corlianò M, Tosi D, Santoro R, Nigro P, Poggio P, Bulfamante G, Lombardi F, Pompilio G. Journal of translational medicine. 2018 December;16:352. [Full Text Article] [PubMed:30541573] [PMC:PMC6292173]
4
CD4+ primary T cells expressing HCV-core protein upregulate Foxp3 and IL-10, suppressing CD4 and CD8 T cells. Cecilia Fernandez-Ponce, Margarita Dominguez-Villar, Enrique Aguado, Francisco Garcia-Cozar. PloS one. 2014 January;9:e85191. [Full Text Article] [PubMed:24465502] [PMC:PMC3896374]
5
Obesity reduces mammary epithelial cell TGFß1 activity through macrophage-mediated extracellular matrix remodeling. Tamara Chamberlin, Victoria Thompson, Lauren E Hillers-Ziemer, Brenna N Walton, Lisa M Arendt. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 June;34:8611-8624. [Full Text Article] [PubMed:32359100] [PMC:PMC7317547] Related Antibodies: LS-B14345.
6
Pre- and Neonatal Exposure to Lead (Pb) Induces Neuroinflammation in the Forebrain Cortex, Hippocampus and Cerebellum of Rat Pups. Karina Chibowska, Jan Korbecki, Izabela Gutowska, Emilia Metryka, Maciej Tarnowski, Marta Goschorska, Katarzyna Barczak, Dariusz Chlubek, Irena Baranowska-Bosiacka. International journal of molecular sciences. 2020 February;21: [Full Text Article] [PubMed:32041252] [PMC:PMC7037720]
7
Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury. Wei-Zhong Ying, Xingsheng Li, Sunil Rangarajan, Wenguang Feng, Lisa M Curtis, Paul W Sanders. The Journal of clinical investigation. 2019 June;130:2792-2806. [Full Text Article] [PubMed:31205024] [PMC:PMC6597222]
8
Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NF?B-mediated inflammation in IUGR mice. Yan Xing, Hongling Wei, Xiumei Xiao, Zekun Chen, Hui Liu, Xiaomei Tong, Wei Zhou. Biology open. 2020 April;9: [Full Text Article] [PubMed:32139393] [PMC:PMC7197710]
9
Circulating TGF-ß1 as the potential epithelial mesenchymal transition-biomarker for diagnosis of cholangiocarcinoma. Phongsaran Kimawaha, Apinya Jusakul, Prem Junsawang, Watcharin Loilome, Narong Khuntikeo, Anchalee Techasen. Journal of gastrointestinal oncology. 2020 Apr;11:304-318. [Full Text Article] [PubMed:32399272] [PMC:PMC7212108] Related Antibodies: LS-C104537.
10
Histopathological and immunohistochemical evaluation of cellular response to a woven and electrospun polydioxanone (PDO) and polycaprolactone (PCL) patch for tendon repair. Mustafa Rashid, Jayesh Dudhia, Stephanie G Dakin, Sarah J B Snelling, Roberta De Godoy, Pierre-Alexis Mouthuy, Roger K W Smith, Mark Morrey, Andrew J Carr. Scientific reports. 2020 Mar;10:4754. [Full Text Article] [PubMed:32179829] [PMC:PMC7076042]
11
Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NF?B-mediated inflammation in the IUGR mice. Yan Xing, Hongling Wei, Xiumei Xiao, Zekun Chen, Hui Liu, Xiaomei Tong, Wei Zhou. Biology open. 2020 January;9: [Full Text Article] [PubMed:34004666]
12
Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions. Farideh Amirrad, Rajasekharreddy Pala, Kiumars Shamloo, Brian S Muntean, Surya M Nauli. Frontiers in cardiovascular medicine. 2021 December;8:772961. [Full Text Article] [PubMed:34901233] [PMC:PMC8661014]
13
Physiological Fluid Flow Moderates Fibroblast Responses to TGF-ß1. Sadhvi Nithiananthan, Aileen Crawford, Johnathan Cooper Knock, Daniel W Lambert, Simon A Whawell. Journal of cellular biochemistry. 2017 April;118:878-890. [Full Text Article] [PubMed:27748539] Related Antibodies: LS-C161825.
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TGFB1 / TGF Beta 1 Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal (310-390 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TGFB1 / TGF Beta 1 Antibody - TGFB1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human breast carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
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TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal (aa22-50) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
TGFB1 / TGF Beta 1 Antibody - Anti-TGFB1 / TGF Beta 1 antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IHC, IHC-P, Neut, WB
Unconjugated
50 µg/$460
TGFB1 / TGF Beta 1 Antibody - Anti-TGFB1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Cancer
TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$515
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TGFB1 / TGF Beta 1 Goat anti-Human Polyclonal Antibody
Human
ELISA, Flo, ICC, IHC, Neut, WB
Unconjugated
100 µg/$292
TGFB1 / TGF Beta 1 Antibody
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TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
100 µl/$332
TGFB1 / TGF Beta 1 Antibody - Mouse Lymph node cell lysate. Antibody concentration: 1.25 ug/ml. Gel concentration: 8%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TGFB1 / TGF Beta 1 Rabbit anti-Mouse Polyclonal (aa151-200) Antibody
Mouse
WB
Unconjugated
100 µl/$397
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TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal (PE) Antibody
Human
Flo
PE Conjugated
100 Tests/$872
TGFB1 / TGF Beta 1 Antibody - Western Blot; Sample: Recombinant TGFb1, Human.
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TGFB1 / TGF Beta 1 Rabbit anti-Human Polyclonal (aa279-390) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$281; 200 µl/$312; 500 µl/$413; 1 ml/$464; 2 ml/$565; 5 ml/$969
TGFB1 / TGF Beta 1 Antibody - Anti-Human TGF-ß1 Western Blot Unreduced
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TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal Antibody
Mouse, Human, Monkey
WB
Unconjugated
500 µg/$326
TGFB1 / TGF Beta 1 Antibody - Western blot using TGF beta1 mouse monoclonal antibody against truncated TGF beta1 recombinant protein.
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TGFB1 / TGF Beta 1 Mouse anti-Human Monoclonal (4F9C10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$355
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
TGFB1 / TGF Beta 1 Protein - Recombinant Transforming Growth Factor Beta 1 By SDS-PAGE
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E. coli
His, N-Terminal
14.3 kDa
10 µg/$290; 50 µg/$500; 100 µg/$797; 200 µg/$997; 1 mg/$2,139; 500 µg/$1,662; 5 mg/$3,487; 2 mg/$2,329
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates, Urine
1 Plate/$669
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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Human Cells
None
Less than 1.0 EU/µg protein (determined by LAL method).
12.8kD
10 µg/$321; 50 µg/$534; 500 µg/$1,869; 1 mg/$2,991
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
12 x 8-Well Microstrips
Human
157 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum
1 Plate/$618
TGFB1 / TGF Beta 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Urine
1 Plate/$636
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CHO Cells
Human IgG4 Fc
Less than 0.06 EU/µg protein (determined by LAL method).
67 kDa
100 µg/$519
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$598
TGFB1 / TGF Beta 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Bovine
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$889
TGFB1 / TGF Beta 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$598
TGFB1 / TGF Beta 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Platelet-Poor Plasma, Serum, Tissue Homogenates
1 Plate/$818
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TGFB1 / TGF Beta 1 Goat anti-Human Polyclonal Antibody
Human
ELISA, Neut
Unconjugated
100 µg/$444; 1 mg/$1,017
Viewing 1-25 of 332 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).