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Anti-TGF-Beta Antibody (clone TB21) IHC-plus™ LS-B4772

Note: This antibody replaces LS-C18188

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
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Most Popular TGF-Beta Antibodies

Anti-TGF-Beta Antibody (clone TB21) IHC-plus™ LS-B4772
Mouse Monoclonal [clone TB21] (IgG1,k) to Human TGF-Beta
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA, Functional Assay, Neutralization
Unconjugated
Immunohistochemistry Image
Anti-TGF-Beta Antibody (PE) LS-C126397
Goat Polyclonal (IgG) to Human TGF-Beta
Human
Flow Cytometry
PE Conjugated

100% Guaranteed 100% Guaranteed Publications Publications (1)
Mouse Monoclonal [clone TB21] (IgG1,k) to Human TGF-Beta
Human
IHC - Paraffin, IHC - Frozen, Western blot, ELISA, Functional Assay, Neutralization
Unconjugated

Details

Human TGF-Beta
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [TB21]
Unconjugated
Protein G purified
Unmodified

Applications

  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen
  • Western blot
  • ELISA
  • Functional Assay
  • Neutralization

Specificity and Use

TGF-Beta antibody was raised against tGF-b from human platelets.
Recognizes both human platelet-derived and recombinant TGF-beta.
Suitable for use in Western Blot, ELISA, Neutralization and Immunohistochemistry. Neutralization: Neutralizes TGF-beta activity in vitro in an inhibition assay of CCL/64 cell growth and the growth promoting action of TGF-beta in the NRK-49F colony forming assay. The effect of microinjection of this antibody into one blastomere of two cell stage Xenopus embryos indicated that it was able to neutralize effectively the bioactivity of TGF-beta in vivo. Immunohistochemistry (formalin-fixed, paraffin-embedded, frozen): 1:1000. Has been used to demonstrate TGF-beta in ovine ovarian tissue and human breast carcinoma. As a consequence of the intense staining of the erythrocytes it is possible to locate a single cell within the ovarian stroma making it useful in locating very fine capillary networks within tissue. Western Blot: 5-20 ng/ml will allow visualization of 100 ng/lane of TGF-beta. Recognizes the dimeric (25kD) and monomeric (12.5kD) forms of TGF-beta under both non-reducing and reducing conditions respectively.

Packaging

PBS, pH 7.0.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.
For research use only.

Publications (1)

1
TGF- beta -inducible microRNA-183 silences tumor-associated natural killer cells. Donatelli SS, Zhou JM, Gilvary DL, Eksioglu EA, Chen X, Cress WD, Haura EB, Schabath MB, Coppola D, Wei S, Djeu JY. Proceedings of the National Academy of Sciences of the United States of America. 2014 Mar;111:4203-8. [Full Text Article] [PubMed:24586048] [PMC:PMC3964044]

About TGF-Beta

Transforming growth factor beta is a secreted protein that controls proliferation, cellular differentiation, and other functions in most cells. It is a type of cytokine which plays a role in immunity, cancer, bronchial asthma, lung fibrosis, heart disease, diabetes, Hereditary hemorrhagic telangiectasia, Marfan syndrome, Vascular Ehlers-Danlos syndrome, Loeys–Dietz syndrome, Parkinson's disease, Chronic kidney disease, Multiple Sclerosis and AIDS.

Immunohistochemistry

Immunohistochemistry
Anti-TGF-Beta antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4772 concentration 10 ug/ml.

Immunohistochemistry

Immunohistochemistry
Anti-TGF-Beta antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4772 concentration 10 ug/ml.

Requested From: United States
Date Requested: 12/9/2016

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