Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
TFF1 / pS2 antibody was raised against a Synthetic peptide of 28 amino acid residues corresponding to CFDDTVRGVPWCF-YPNTIDVPPEEECEF (aa 57-84) from C-terminus of human pS2 protein. Percent identity by BLAST analysis: Human, Horse (100%); Gorilla, Gibbon, Cat, Bovine (92%); Monkey, Marmoset, Mouse, Rat, Panda, Bat, Dog (85%).
The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.
Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. TFF1, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors.
Formalin-fixed, paraffin-embedded human breast cancer stained with peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells. This image was taken for the unmodified form of this product. Other forms have not been tested.