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TFEB

transcription factor EB

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.

Gene Name: transcription factor EB
Family/Subfamily: Transcription factor
Synonyms: TFEB, ALPHATFEB, BHLHE35, T-cell transcription factor EB, TCFEB, Transcription factor EB
Target Sequences: NM_007162 NP_009093.1 P19484

Publications (2)

1
RIP3 impedes transcription factor EB to suppress autophagic degradation in septic acute kidney injury. Ruizhao Li , Xingchen Zhao , Shu Zhang , Wei Dong, Li Zhang, Yuanhan Chen, Zhilian Li, Huan Yang, Ying Huang, Zhiyong Xie, Weidong Wang, Chunling Li, Zhiming Ye, Zheng Dong, Xinling Liang. Cell death & disease. 2021 June;12:593. [Full Text Article] [PubMed:34103472] [PMC:PMC8187512]
2
RanBP9 overexpression reduces dendritic arbor and spine density. Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana MK. Neuroscience. 2014 Apr;265:253-62. [Full Text Article] [PubMed:24486966] [PMC:PMC3972333] Related Antibodies: LS-C118813.

☰ Filters
Antibodies (51)
Proteins (4)
Over-Expression Lysate (2)
Primary (51)
Recombinant (2)
TFEB (55)
Human (50)
Mouse (19)
Rat (12)
Bat (7)
Bovine (11)
Chimpanzee (9)
Dog (7)
Gibbon (9)
Goat (7)
Guinea pig (3)
Hamster (4)
Horse (10)
Monkey (10)
Pig (8)
Rabbit (10)
IHC (13)
IHC-P (7)
WB (45)
DB (2)
ELISA (19)
IF (7)
IP (4)
Peptide-ELISA (3)
rabbit (45)
mouse (5)
goat (1)
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IgG1 (4)
IgG1,k (1)
monoclonal mc (5)
polyclonal pc (45)
recombinant monoclonal rmc (1)
319C2a (2)
S1 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (6)
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HRP Conjugated (6)
PE Conjugated (1)
Unconjugated (31)
C-Terminus (8)
aa271-300 (7)
aa170-219 (4)
aa395-444 (4)
aa1-220 (2)
10-90 aa, N-terminal (1)
N-Terminus (1)
aa10-59 (1)
aa15-64 (1)
aa289-301 (1)
aa325-375 (1)
aa426-476 (1)
aa6-51 (1)
No (54)
Yes (1)
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Purified (1)
TFEB Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TFEB Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using TFEB Antibody. The picture on the right is blocked with the synthesized peptide.
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TFEB Rabbit anti-Human Polyclonal (aa10-59) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
TFEB Antibody - Anti-TFEB antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$545
TFEB Antibody - Anti-TFEB antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50 µg/$460
TFEB Antibody - Immunofluorescence of monoclonal antibody to TFEB on HeLa cell. [antibody concentration 20 ug/ml]
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TFEB Mouse anti-Human Monoclonal (S1) Antibody
Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$423
TFEB Antibody - Western blot of TFEB antibody
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TFEB Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
TFEB Antibody - Western blot analysis of TFEB expression in A549 (A); NIH3T3 (B); H9C2 (C) whole cell lysates.
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TFEB Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
WB
Unconjugated
100 µl/$299
TFEB Antibody
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TFEB Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
TFEB Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TFEB Rabbit anti-Human Polyclonal (aa15-64) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$515
TFEB Antibody - A: Marker, B: HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TFEB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$397
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
TFEB Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
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TFEB Rabbit anti-Human Polyclonal (aa1-220) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
TFEB Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using TFEB Antibody at dilution of 1:100
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TFEB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$294; 100 µg/$360
Select
TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
100 µg/$357
TFEB Antibody - Immunofluorescence analysis of HeLa cells using TFEB Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
Select
TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TFEB Antibody - Immunohistochemistry of paraffin-embedded human tonsil using antibody at 1:100 dilution.
Select
TFEB Rabbit anti-Human Polyclonal (aa1-220) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Select
TFEB Rabbit anti-Human Polyclonal (aa6-51) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$314; 100 µl/$391
TFEB Antibody - Western blot of TFEB expression in Mouse lung tissue lysates,The lane on the left is treated with the antigen-specific peptide.
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TFEB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
TFEB Antibody - Detection of Human TFEB by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-TFEB used at a dilution of 1:1000 (1 Detection: DAB.
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TFEB Rabbit anti-Human Polyclonal (aa426-476) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Select
TFEB Rabbit anti-Human Polyclonal (aa271-300) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
TFEB Rabbit anti-Human Polyclonal (aa271-300) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
TFEB Rabbit anti-Human Polyclonal (aa271-300) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
TFEB Mouse anti-Human Monoclonal (319C2a) Antibody
Human
DB, WB
Unconjugated
50 µg/$474
TFEB Antibody - Western blot analysis of immunized recombinant protein, using anti-TFEB monoclonal antibody.
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TFEB Mouse anti-Human Monoclonal (319C2a) Antibody
Human
DB, WB
Unconjugated
100 µg/$486
Select
TFEB Rabbit anti-Human Polyclonal (aa325-375) Antibody
Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 55 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).