Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role, required to recruit a number of factors and enzymes required for telomere protection, including the shelterin complex, TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection.
Immunofluorescent staining of TRF2-bound telomeres in human HeLa cells (Courtesy of Fotiadou, et al, 2004).
Western blot of TRF2 in human Jurkat cell lysate using TRF2 antibody at 2 ug/ml.
Intracellular flow cytometry of TRF2 in 10^6 human Jurkat cells using 0.1 ug of LS-C606. The shaded histogram represents cells alone, blue represents isotype control and red represents LS-C606, anti-TRF2.
Requested From: United States
Date Requested: 1/16/2017