Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Mouse, Rat, Bovine (at least 90% immunogen sequence identity)
Western blot (1 - 10 µg/ml)
ELISA (1:10000 - 1:100000)
Specificity and Use
TEK / TIE2 antibody was raised against 18aa peptide of human Tie2. Location: ~N-terminal, Extracellular. No significant sequence homology is seem with Tie1. Species Sequence Homology: Mouse, rat - 100%; Bovine - 94%.
Recognizes human Tie2.
Suitable for use in ELISA and Western Blot.
PBS, pH 7.2, 0.1% BSA.
+4°C or -20°C, Avoid repeated freezing and thawing.
Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis.