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TEAD4
TEA domain family member 4
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
| Gene Name: | TEA domain family member 4 |
| Synonyms: | TEAD4, EFTR-2, HRTEF-1B, RTEF1, RTEF-1, TCF13L1, TEF-3, TEAD-4, TEF3, Transcription factor 13-like 1, Transcription factor RTEF-1, TEFR-1, TEA domain family member 4 |
| Target Sequences: | NM_003213 NP_003204.2 Q15561 |
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