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TDO2

tryptophan 2,3-dioxygenase

TDO2 is a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism.

Gene Name: tryptophan 2,3-dioxygenase
Synonyms: TDO2, TDO, TO, TRPO, Tryptophan pyrrolase, Tryptophan oxygenase, Tryptophan 2,3-dioxygenase, Tryptophanase, Tryptamin 2,3-dioxygenase
Target Sequences: NM_005651 NP_005642.1 P48775

Publications (4)

1
Prognostic Significance of Tryptophan Catabolism in Adult T-cell Leukemia/Lymphoma. Masaki A, Ishida T, Maeda Y, Suzuki S, Ito A, Takino H, Ogura H, Totani H, Yoshida T, Kinoshita S, Narita T, Ri M, Kusumoto S, Inagaki A, Komatsu H, Niimi A, Ueda R, Utsunomiya A, Inagaki H, Iida S. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015 21:2830-9. (IHC, IF; Human) [Full Text Article] [PubMed:25788494] Related Antibodies: LS-C174023.
2
Restoration of energy homeostasis by SIRT6 extends healthy lifespan. A Roichman , S Elhanati , M A Aon, I Abramovich, A Di Francesco, Y Shahar, M Y Avivi, M Shurgi, A Rubinstein, Y Wiesner, A Shuchami, Z Petrover, I Lebenthal-Loinger, O Yaron, A Lyashkov, C Ubaida-Mohien, Y Kanfi, B Lerrer, P J Fernández-Marcos, M Serrano, E Gottlieb, R de Cabo, H Y Cohen. Nature communications. 2021 May;12:3208. [Full Text Article] [PubMed:34050173] [PMC:PMC8163764] Related Antibodies: LS-C748245.
3
Expression of Tryptophan 2,3-Dioxygenase in Metastatic Uveal Melanoma. Mizue Terai, Eric Londin, Ankit Rochani, Emma Link, Bao Lam, Gagan Kaushal, Alok Bhushan, Marlana Orloff, Takami Sato. Cancers. 2020 Feb;12:405. [Full Text Article] [PubMed:32050636] [PMC:PMC7072257] Related Antibodies: LS-B5791.
4
The Effect of Systemic Nitroglycerin Administration on the Kynurenine Pathway in the Rat. Nagy-Grócz G, Laborc KF, Veres G, Bajtai A, Bohár Z, Zádori D, Fejes-Szabó A, Spekker E, Vécsei L, Párdutz Á. Frontiers in neurology. 2017 8:278. (WB; Rat) [Full Text Article] [PubMed:28659861] [PMC:PMC5469907] Related Antibodies: LS-C111058.
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☰ Filters
Antibodies (28)
Proteins (11)
ELISA Kits (6)
Competitive EIA (1)
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Over-Expression Lysate (2)
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TDO2 (45)
Human (31)
Mouse (5)
Rat (4)
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Chimpanzee (2)
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Guinea pig (2)
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IHC (9)
IHC-P (7)
WB (26)
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rabbit (19)
mouse (9)
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monoclonal mc (9)
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96-Well Strip Plate (6)
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aa71-120 (3)
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Human (7)
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293T Cells (1)
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TDO2 Antibody - Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDO2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
TDO2 Antibody - Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDO2 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
TDO2 Antibody - Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDO2 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
TDO2 Antibody - Anti-TDO2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDO2 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Dog, Human, Monkey, Gibbon
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
TDO2 Antibody - IHC of paraffin-embedded Human breast tissue using anti-TDO2 mouse monoclonal antibody.
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TDO2 Mouse anti-Human Monoclonal (OTI2A4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$450
TDO2 Antibody - IHC of paraffin-embedded Human breast tissue using anti-TDO2 mouse monoclonal antibody.
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TDO2 Mouse anti-Human Monoclonal (Carrier-free) (OTI2A4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TDO2 Antibody - Anti-TDO / TPH2 / TDO2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TDO2 Mouse anti-Human Monoclonal (4G2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
TDO2 Antibody - TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDO2 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
TDO2 Antibody - TDO2 antibody Western blot of Fetal Small Intestine lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TDO2 Rabbit anti-Human Polyclonal (aa71-120) (Biotin) Antibody
Xenopus, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Human, Monkey, Chimpanzee, Gibbon
WB
Biotin Conjugated
100 µl/$469
TDO2 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.
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TDO2 Mouse anti-Human Monoclonal (OTI1D1) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
TDO2 Antibody - Immunohistochemistry of paraffin-embedded Human mammary gland tissue.
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TDO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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Yeast
His
49.7 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
TDO2 Antibody - Western blot analysis of extracts of various cell lines, using TDO2 antibody at 1:500 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 5s.
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TDO2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TDO2 Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDO2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TDO2.
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TDO2 Mouse anti-Human Monoclonal (OTI1B1) Antibody
Human
WB
Unconjugated
100 µl/$434
TDO2 Antibody - TDO2 Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The TDO2 antibody detected the TDO2 protein (arrow).
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TDO2 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
WB
Unconjugated
400 µl/$393
TDO2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
TDO2 Protein
Select
Yeast
His
49.9 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
TDO2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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293T Cells
Myc-DDK (Flag)
47.7 kDa
20 µg/$150
TDO2 Antibody - Anti-TDO / TPH2 / TDO2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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TDO2 Mouse anti-Human Monoclonal (Carrier-free) (4G2) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TDO2 Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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TDO2 Rabbit anti-Human Polyclonal (aa1-30) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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TDO2 Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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TDO2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
TDO2 Antibody - Western blot analysis using anti-TDO (human), pAb at 1:2000 dilution. 1: Human TDO (His-tagged). 2: Human IDO (His-tagged). 3: Mouse IDO (His-tagged). 4: SH-sy5y cell lysate. 5: Unrelated protein (His-tagged) (negative control).
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TDO2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$323
Viewing 1-25 of 45 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).