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TARBP2 / TRBP2

TAR (HIV-1) RNA binding protein 2

Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

Gene Name: TAR (HIV-1) RNA binding protein 2
Synonyms: TARBP2, TAR RNA binding protein 2, TRBP1, TRBP2, TAR RNA-binding protein 2, TRBP, LOQS
Target Sequences: NM_004178 NP_004169.3 Q15633

Publications (1)

1
Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex. Liao JM, Zhou X, Gatignol A, Lu H. Oncogene. 2014 33:4916-23. (WB; Human) [Full Text Article] [PubMed:24141778] [PMC:PMC4026346]

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Antibodies (28)
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TARBP2 / TRBP2 (43)
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TARBP2 / TRBP2 Antibody - IHC of normal human brain using antibody (TRBP) at 5 ug/ml.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa340-390) Antibody
Chicken, Rat, Horse, Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$386
TARBP2 / TRBP2 Antibody - Anti-TARBP2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (2G10) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
TARBP2 / TRBP2 Antibody - TARBP2 monoclonal antibody (M02), clone 2H1. Western blot of TARBP2 expression in Jurkat.
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (2H1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
TARBP2 / TRBP2 Antibody - HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa25-74) Antibody
Human
WB
Unconjugated
100 µl/$397
TARBP2 / TRBP2 Antibody - 1:100 staining human gastric tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
TARBP2 / TRBP2 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-TARBP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150).
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (OTI7C1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
TARBP2 / TRBP2 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-TARBP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0)(1:150)
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (Carrier-free) (OTI7C1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
TARBP2 / TRBP2 Antibody
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321
TARBP2 / TRBP2 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TARBP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120 oC for 3 min. (1:150)
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (OTI2C12) Antibody
Human
IHC, WB
Unconjugated
100 µl/$434
TARBP2 / TRBP2 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-TARBP2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120 oC for 3 min. (1:150)
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (Carrier-free) (OTI2C12) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
TARBP2 / TRBP2 Antibody
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa38-281) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
TARBP2 / TRBP2 Antibody - Immunofluorescence analysis of A549 cells.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
TARBP2 / TRBP2 Antibody - Immunohistochemistry of paraffin-embedded human endometrial cancer using antibody at 1:100 dilution.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa1-366) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
TARBP2 / TRBP2 Antibody - TARBP2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa60-89) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TARBP2 / TRBP2 Antibody - Western blot of TARBP2 expression in transfected 293T cell line by TARBP2 monoclonal antibody (M08), clone 1G6.
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TARBP2 / TRBP2 Mouse anti-Human Monoclonal (1G6) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
TARBP2 / TRBP2 Antibody - TRBP2 Antibody western blot testing of human samples
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human, Primate
WB
Unconjugated
25 µg/$364; 100 µg/$511
TARBP2 / TRBP2 Antibody - Fig-1: Western blot analysis of TRBP. Anti-TRBP antibody  was used at 6 µg/ml on Hela lysate.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal (aa150-366) Antibody
Human
WB
Unconjugated
25 µg/$281; 100 µg/$400
TARBP2 / TRBP2 Antibody - Immunochemical staining of human TARBP2 in human brain with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.
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TARBP2 / TRBP2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P
Unconjugated
100 µl/$412
Viewing 1-25 of 43 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).