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TAP2

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.

Gene Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Family/Subfamily: Transporter , ATP-binding cassette - ABCB/MDR
Synonyms: TAP2, ABC transporter, MHC 2, ABCB3, APT2, Antigen peptide transporter 2, D6S217E, ABC18, Ham2, Peptide supply factor 2, Peptide transporter PSF2, Peptide transporter TAP2, PSF2, Y1, PSF-2, RING11
Target Sequences: NM_000544 NP_000535.3 Q03519

☰ Filters
Antibodies (29)
Proteins (6)
ELISA Kits (3)
Competitive EIA (1)
Custom (2)
Over-Expression Lysate (2)
Primary (29)
Recombinant (4)
TAP2 (38)
Human (22)
Mouse (6)
Rat (14)
IHC (9)
IHC-P (1)
WB (23)
ELISA (7)
ICC (1)
IF (3)
Peptide-ELISA (1)
rabbit (29)
Product Group
IHCPlus (1)
Ig (1)
IgG (9)
polyclonal pc (29)
96-Well Strip Plate (3)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (3)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (3)
Unconjugated (10)
C-Terminus (6)
N-Terminus (1)
aa611-651 (1)
No (38)
Plasma (1)
Serum (1)
GST (2)
His-T7, N-terminus (2)
Myc-DDK (Flag) (2)
Human (4)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
TAP2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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TAP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
TAP2 Antibody - Immunofluorescent analysis of TAP2 staining in U2OS cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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TAP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
TAP2 Antibody - Western blot analysis of extracts of placenta using TAP2 antibody. The lane on the left is treated with the antigen-specific peptide.
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TAP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
TAP2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
Select
TAP2 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
ELISA, IHC
Biotin Conjugated
200 µl/$952
Select
TAP2 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
ELISA, IHC
FITC Conjugated
200 µl/$952
Select
TAP2 Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody
Human
ELISA, IHC
HRP Conjugated, Azide-free
200 µl/$952
Select
TAP2 Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody
Human
ELISA, IHC
PE Conjugated
200 µl/$952
Select
TAP2 Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody
Human
ELISA, IHC
APC Conjugated
200 µl/$952
Select
TAP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
TAP2 Antibody - Western blot.
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TAP2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
TAP2 Antibody - All lanes: Anti-TAP2 Antibody (N-Term) at 1:2000 dilution Lane 1: Human placenta lysate Lane 2: Jurkat whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size: 76 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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TAP2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$393
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
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TAP2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702; 2 ml/$939; 5 ml/$1,593
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (Cy3) Antibody
Human
WB
Cy3 Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (APC) Antibody
Human
WB
APC Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401; 2 ml/$1,961; 5 ml/$3,676
TAP2 Antibody - Western Blot; Sample: Recombinant protein.
Select
TAP2 Rabbit anti-Human Polyclonal (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008; 2 ml/$1,308; 5 ml/$2,451
TAP2 Antibody - TAP2 antibody Western blot. All lanes: Anti TAP2 at 0.5 ug/ml. WB: HELA Whole Cell Lysate at 40 ug. Predicted band size: 87 kD. Observed band size: 87 kD.
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TAP2 Rabbit anti-Human Polyclonal (aa611-651) Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
TAP2 Antibody
Select
TAP2 Rabbit anti-Rat Polyclonal Antibody
Rat
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
TAP2 Antibody
Select
TAP2 Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat
WB
Biotin Conjugated
100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464
TAP2 Antibody
Select
TAP2 Rabbit anti-Rat Polyclonal (FITC) Antibody
Rat
WB
FITC Conjugated
100 µl/$359; 200 µl/$423; 500 µl/$655; 1 ml/$816; 2 ml/$1,055; 5 ml/$1,863
TAP2 Antibody
Select
TAP2 Rabbit anti-Rat Polyclonal (Cy3) Antibody
Rat
WB
Cy3 Conjugated
100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661
Viewing 1-25 of 38 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).