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Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.
Gene Name: | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa |
Synonyms: | TAF4B, TAF(II)105, TAFII105, TAF2C2, TAFII-105 |
Target Sequences: | Y09321 CAA70499.1 Q92750 |
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