Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Rat Monoclonal [clone G8.8] (IgG2a) to Mouse TACSTD1 / EPCAM
IHC - Frozen, ICC, Western blot, Immunoprecipitation, Flow Cytometry
Mouse Monoclonal (IgG1,k) to Human TACSTD1 / EPCAM
IHC - Paraffin
Human TACSTD1 / EPCAM
Human (tested or 100% immunogen sequence identity)
Tissue culture supernatant
IHC - Paraffin (1:10)
Specificity and Use
TACSTD1 / EPCAM antibody was raised against mCF-7 human breast carcinoma cell line.
Recognizes Epithelial Specific Antigen. Reacts with a transmembrane glycoprotein present on most normal and malignant epithelia. Mesothelial cells derived tumors are rarely positive. Species cross-reactivity: Human.
Immunohistology (Formalin/paraffin): (Use Ab at 1:10 for 30 min at RT) Staining of formalin/paraffin tissues requires digestion of tissue sections with pepsin at 1 mg/ml Tris-HCl, pH 2.0 for 15 min at RT or 10 min at 37C). Positive control: Breast carcinoma.
0.09% sodium azide.
Short term: +4°C; Long term: Add glycerol (40-50%) -20°C.
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.