Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone VU-1D9] (IgG1) to Human TACSTD1 / EPCAM
IHC - Paraffin, Western blot, Flow Cytometry, ELISA
Human TACSTD1 / EPCAM
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [VU-1D9]
IHC - Paraffin (1:100)
Specificity and Use
Ep-Cam (also called ESA, EGP40, 17-1A antigen, KSA, GA7333-2) is a 40kD epithelial protein expressed on baso-lateral cell surfaces in very many epithelial tissues (but absent from mesothelial tissues). The extracellular domain has a cysteine-rich repeat and a small domain with homology to nidogen. It is a homophyllic cell-cell adhesion molecule, recently called Ep-CAM (Litvinov et al., 1994). It reacts with most epithelial cells and carcinomas.
The antibody can be used for flow cytometry, ELISA, immunohistochemistry on paraffin-embedded sections and Western blotting.
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.