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SYP / Synaptophysin

synaptophysin

Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release.

Gene Name: synaptophysin
Synonyms: SYP, MRX, Synaptophysin, MRXSYP
Target Sequences: X06389 CAA29686.1 P08247

Publications (7)

1
Therapeutically targeting cyclin D1 in primary tumors arising from loss of Ini1. Smith ME, Cimica V, Chinni S, Jana S, Koba W, Yang Z, Fine E, Zagzag D, Montagna C, Kalpana GV. Proceedings of the National Academy of Sciences of the United States of America. 2011 108:319-24. (IHC) [PubMed:21173237] [PMC:PMC3017186]
2
Transplantation of hUC-MSCs seeded collagen scaffolds reduces scar formation and promotes functional recovery in canines with chronic spinal cord injury. Li X, Tan J, Xiao Z, Zhao Y, Han S, Liu D, Yin W, Li J, Li J, Wanggou S, Chen B, Ren C, Jiang X, Dai J. Scientific reports. 2017 7:43559. (WB; Human) [Full Text Article] [PubMed:28262732] [PMC:PMC5337930] Related Antibodies: LS-C174790.
3
Behavioral alterations are associated with vitamin B12 deficiency in the transcobalamin receptor/CD320 KO mouse. Arora K, Sequeira JM, Hernández AI, Alarcon JM, Quadros EV. PloS one. 2017 12:e0177156. (WB; Human) [Full Text Article] [PubMed:28545069] [PMC:PMC5436650] Related Antibodies: LS-C203763.
4
Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. Tucsek Z, Noa Valcarcel-Ares M, Tarantini S, Yabluchanskiy A, Fülöp G, Gautam T, Orock A, Csiszar A, Deak F, Ungvari Z. GeroScience. 2017 (ICC, WB; Human, Rat) [Full Text Article] [PubMed:28664509] [PMC:PMC5636782]
5
SIX2 Regulates Human ß Cell Differentiation from Stem Cells and Functional Maturation In Vitro. Leonardo Velazco-Cruz, Madeleine M Goedegebuure, Kristina G Maxwell, Punn Augsornworawat, Nathaniel J Hogrebe, Jeffrey R Millman. Cell reports. 2020 May;31:107687. [Full Text Article] [PubMed:32460030] [PMC:PMC7304247] Related Antibodies: LS-C174787.
6
Noradrenergic fibers are associated with beta-cell dedifferentiation and impaired beta-cell function in humans. F Cinti, T Mezza, I Severi, M Suleiman, C M A Cefalo, G P Sorice, S Moffa, F Impronta, G Quero, S Alfieri, A Mari, A Pontecorvi, L Marselli, S Cinti, P Marchetti, A Giaccari. Metabolism: clinical and experimental. 2021 January;114:154414. [Full Text Article] [PubMed:33129839] Related Antibodies: LS-C174787.
7
pHERV-W envelope protein fuels microglial cell-dependent damage of myelinated axons in multiple sclerosis. David Kremer, Joel Gruchot, Vivien Weyers, Lisa Oldemeier, Peter Göttle, Luke Healy, Jeong Ho Jang, Yu Kang T Xu, Christina Volsko, Ranjan Dutta, Bruce D Trapp, Hervé Perron, Hans-Peter Hartung, Patrick Küry. Proceedings of the National Academy of Sciences of the United States of America. 2019 Jul;116:15216-15225. [Full Text Article] [PubMed:31213545] [PMC:PMC6660731]
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SYP / Synaptophysin Antibody - SYP Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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SYP / Synaptophysin Rabbit anti-Human Polyclonal (aa225-253) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
SYP / Synaptophysin Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-SYP mouse monoclonal antibody.
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SYP / Synaptophysin Mouse anti-Human Monoclonal (OTI3E2) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
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SYP / Synaptophysin Sheep anti-Rat Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
SYP / Synaptophysin Antibody - Anti-SYP mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SYP.
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SYP / Synaptophysin Mouse anti-Human Monoclonal (OTI5H2) Antibody
Dog, Human
IF, WB
Unconjugated
100 µl/$434
SYP / Synaptophysin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
493.8 - 40000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$782
SYP / Synaptophysin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
SYP / Synaptophysin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
SYP / Synaptophysin ELISA Kit
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Sandwich
96-Well Microplate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
SYP / Synaptophysin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$931
SYP / Synaptophysin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$959
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SYP / Synaptophysin Rabbit anti-Rat Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
SYP / Synaptophysin ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
SYP / Synaptophysin Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SYP / Synaptophysin Mouse anti-Human Monoclonal (4A2) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
SYP / Synaptophysin Antibody - Immunohistochemistry: Synaptophysin Antibody - IHC analysis of Synaptophysin in mouse brain.
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SYP / Synaptophysin Rabbit anti-Human Polyclonal (aa230-313) Antibody
Mouse, Human, Primate
ICC, IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
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SYP / Synaptophysin Mouse anti-Human Monoclonal (Concentrated) (SY38) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated, Concentrated
1 ml/$545
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SYP / Synaptophysin Sheep anti-Human Polyclonal Antibody
Human
IHC, WB
Unconjugated
500 µg/$393
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SYP / Synaptophysin Chicken anti-Mouse Polyclonal Antibody
Mouse, Rat
IHC, WB
Unconjugated
100 µl/$393
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SYP / Synaptophysin Mouse anti-Human Monoclonal Antibody
Rat, Hamster, Pig, Cat, Human
IHC-P, WB
Unconjugated
100 µl/$786
SYP / Synaptophysin Antibody - Anti-SYP / Synaptophysin antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
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Cancer Pathology
Cancer
SYP / Synaptophysin Mouse anti-Human Monoclonal (1C9) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$485
SYP / Synaptophysin Antibody - Anti-SYP / Synaptophysin antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Cancer Pathology
Cancer
SYP / Synaptophysin Mouse anti-Human Monoclonal (7H12) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$440
SYP / Synaptophysin Antibody - Immunohistochemical staining of paraffin-embedded human pancreas using anti-SYP clone UMAB112 mouse monoclonal antibody at 1:200 dilution of 0.4mg/mL detection with Polink2 Broad HRP DAB.requires heat-induced epitope retrieval with Citrate pH6.0 at 95-100C 20 minutes. The image shows strong membranous and cytoplasmic staining in the Islets of Langerhans with no staining in the glandular cells.
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SYP / Synaptophysin Mouse anti-Human Monoclonal (UMAB112) Antibody
Human
IF, IHC, PMA, WB
Unconjugated
100 µl/$493
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SYP / Synaptophysin Rabbit anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µl/$465
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SYP / Synaptophysin Mouse anti-Human Monoclonal Antibody
Rat, Hamster, Human
ELISA, IHC, IHC-P, WB
Unconjugated
200 µg/$860
SYP / Synaptophysin Protein - 12.5% SDS-PAGE of human SYP stained with Coomassie Blue
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Wheat Germ Extract
GST
60.17 kDa
10 µg/$479; 25 µg/$670
SYP / Synaptophysin Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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SYP / Synaptophysin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
Viewing 1-25 of 137 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).