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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SYP / Synaptophysin Antibody (clone SY38) LS‑C134864
Synaptophysin antibody LS-C134864 is an unconjugated mouse monoclonal antibody to human Synaptophysin (SYP). Validated for IHC.
1 ml

Popular SYP / Synaptophysin Products

Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot
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Product Description

Synaptophysin antibody LS-C134864 is an unconjugated mouse monoclonal antibody to human Synaptophysin (SYP). Validated for IHC.
About SYP / Synaptophysin
Synaptophysin (Syn1) is an abundant synaptic vesicle membrane protein that contains four transmembrane regions. It forms a high molecular weight complex in the vesicle membrane containing at least four Syn I subunits and an 18 kD protein termed synaptobrevin/VAMP. Syn I is phosphorylated by both serine/threonine and tyrosine kinases on its cytoplasmic tail. Knockout studies in mice have shown that it is not essential for neurotransmitter release. P08247 X06389 CAA29686.1

SYP Antibody, MRX Antibody, Synaptophysin Antibody, MRXSYP Antibody


Human SYP / Synaptophysin
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [SY38]
  • IHC
  • IHC - Paraffin
  • IHC - Frozen
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
The antibody is specific for Synaptophysin. The specificity was ascertained by immunoblotting and immunohistochemistry. The antibody predominantly reacts with a 38 kD transmembrane glycoprotein from synaptic vesicles. Antigen was isolated from presynaptic vesicles. Antigen was isolated from presynaptic vesicles. Antigen location, cytoplasm. Cross-reactivity with rat, mouse and cow.
Staining of normal neuroendocrine and neoplastic neuroendocrine cells in tissue sections. The antibody recognizes presynaptic vesicles of neurons of brain, spinal cord, retina neuromuscular junctions, small vesicles of adrenal medulla and pancreatic islets. The antibody can be used for the characterization of neuroendocrine tumors. The antibody can be used on frozen sections and paraffin embedded tissue, proteolytic or T. U. F. pretreatment is not necessary but may, depending on the length of the fixation period, enhance the staining. As positive control adrenal pheochromocytoma and pancreatic islet cell neoplasm are recommended. A dilution of 1:10 is recommended, based on the Indirect method, with a normal ABC method the dilutions can be 5-10x higher, but the optimal dilution should be tested by serial dilution.
Ascites, 0.1% sodium azide
Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles. Store undiluted.
For research use only.
This antibody carries the LSBio 100% Guarantee.

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Date Requested: 6/23/2018

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