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SYNE3 / C14orf49
spectrin repeat containing, nuclear envelope family member 3
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.
| Gene Name: | spectrin repeat containing, nuclear envelope family member 3 |
| Synonyms: | SYNE3, C14orf49, Nesp3, NET53, Nesprin-3 |
| Target Sequences: | Q6ZMZ3 Q6ZMZ3 |
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