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Anti-SYN / FYN Antibody (aa7-176, clone FYN-59) IHC-plus™ LS-B1657

Note: This antibody replaces LS-C40855

Ordering

Wt. Vol. Conc. Price
50 µg - - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular SYN / FYN Antibodies

Anti-SYN / FYN Antibody (aa13-43) LS-C99379
Rabbit Polyclonal to Human SYN / FYN
Human, Mouse
IHC - Paraffin, Western blot, Flow Cytometry
Unconjugated
Immunohistochemistry Image
Anti-SYN / FYN Antibody (N-Terminus) LS-C330447
Rabbit Polyclonal (IgG) to Human SYN / FYN
Human, Mouse
IHC, Western blot, ELISA
Unconjugated

100% Guaranteed 100% Guaranteed Publications Publications (1)
Mouse Monoclonal [clone FYN-59] (IgG) to Human SYN / FYN
Human, Mouse
IHC - Paraffin, Western blot, Immunoprecipitation
Unconjugated

Details

Human SYN / FYN
Mouse
Human, Mouse (tested or 100% immunogen sequence identity)
IgG Monoclonal [FYN-59]
Unconjugated
Affinity purified
Unmodified

Applications

  • IHC - Paraffin (15 µg/ml)
  • Western blot
  • Immunoprecipitation

Specificity and Use

SYN / FYN antibody was raised against recombinant human FYN.
aa7-176
Partial recombinant human Fyn (aa 7-176) expressed in E coli
Immunohistochemistry: LS-B1657 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B1657 was determined to be 15 ug/ml.

Packaging

Phosphate-buffered solution, pH 7.2, 0.09% sodium azide at 0.5 mg/ml.
+4°C, avoid freezing
For research use only.

Publications (1)

1
Unexpected role for the B cell-specific Src family kinase B lymphoid kinase in the development of IL-17-producing T cells. Laird RM, Laky K, Hayes SM. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6518-27. [PubMed:20974990] [PMC:PMC2989676]

About SYN / FYN

P06241 NM_002037 NP_002028.1

FYN Antibody, C-syn protooncogene Antibody, Fyn kinase Antibody, Fyn tyrosine kinase Antibody, p59-FYN Antibody, SYN Antibody, Src-like kinase Antibody, Src/yes-related novel Antibody, Tyrosine kinase fyn Antibody, Tyrosine kinase p59fyn(T) Antibody, Tyrosine-protein kinase Fyn Antibody, Proto-oncogene c-Fyn Antibody, Proto-oncogene Syn Antibody

Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions.

Immunohistochemistry

Immunohistochemistry
Anti-FYN antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1657 concentration 15 ug/ml.

Western blot

Western blot
Extracts from human PBMC were resolved by electrophoresis, transferred to nitrocellulose, and probed with monoclonal antibody against Fyn. Proteins were visualized using a goat anti-mouse secondary conjugated to HRP and a chemiluminescence detection system.

Requested From: United States
Date Requested: 12/3/2016

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