SUPT6H / SPT6

suppressor of Ty 6 homolog (S. cerevisiae)

Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.

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Products

Antibodies (38)

Proteins (1)

Type

Primary (38)

Recombinant (1)

Target

SUPT6H / SPT6 (39)

Reactivity

Human (38)

Mouse (14)

Rat (11)

Bat (9)

Bovine (12)

Chicken (9)

Chimpanzee (9)

Dog (12)

Gibbon (12)

Guinea pig (12)

Hamster (3)

Horse (12)

Monkey (12)

Orangutan (3)

Pig (12)

Rabbit (12)

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Application

IHC (3)

WB (35)

ELISA (7)

IF (1)

IP (3)

Peptide-ELISA (1)

Host

rabbit (38)

Isotype

IgG (17)

Clonality

polyclonal pc (38)

Format

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (2)

Unconjugated (14)

Epitope

N-Terminus (8)

aa538-666 (8)

aa99-127 (7)

aa1660-1709 (4)

aa71-120 (4)

aa425-475 (2)

aa1050-1100 (1)

aa1553-C-term (1)

Publications

No (39)

Tag

His-T7 (1)

Species

Human (1)

Source

E. coli (1)

Select

Human SUPT6H / SPT6 Protein (Recombinant His-T7) - LS-G16217

Source:

E. coli

Tag:

His-T7

Molecular Weight:

19.5 kDa

Price:

10 µg/$273; 50 µg/$392; 100 µg/$625; 200 µg/$782; 1 mg/$1,847; 500 µg/$1,404; 5 mg/$2,807; 2 mg/$2,029

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SUPT6H / SPT6 Antibody (aa425-475) LS-C287658

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa425-475) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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SUPT6H / SPT6 Antibody LS-C753100

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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SUPT6H / SPT6 Antibody (aa1050-1100) LS-C287660

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa1050-1100) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

SUPT6H / SPT6 Antibody (aa99-127) LS-C325503

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

SUPT6H / SPT6 Antibody (aa99-127, Biotin) LS-C270741

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

SUPT6H / SPT6 Antibody (aa99-127, FITC) LS-C270742

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

SUPT6H / SPT6 Antibody (aa99-127, APC) LS-C270740

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

SUPT6H / SPT6 Antibody (aa99-127, Azide-free, HRP) LS-C270743

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

SUPT6H / SPT6 Antibody (aa99-127, PE) LS-C270744

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

Select

SUPT6H / SPT6 Antibody LS-C803630

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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SUPT6H / SPT6 Antibody LS-C833765

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

SUPT6H / SPT6 Antibody (aa425-475) LS-C286459

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa425-475) Antibody

Reactivity:

Mouse, Human

Applications:

IHC

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

Select

SUPT6H / SPT6 Antibody (N-Terminus) LS-C31490

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

Select

SUPT6H / SPT6 Antibody (N-Terminus, HRP) LS-C436698

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$442

Select

SUPT6H / SPT6 Antibody (N-Terminus, Biotin) LS-C436696

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$442

Select

SUPT6H / SPT6 Antibody (N-Terminus, FITC) LS-C436697

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Chicken, Bovine, Rabbit, Dog, Guinea pig, Pig, Horse, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$442

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SUPT6H / SPT6 Antibody (aa71-120) LS-C109784

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa71-120) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SUPT6H / SPT6 Antibody (N-Terminus) LS-C201276

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SUPT6H / SPT6 Antibody (aa1660-1709) LS-C205693

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa1660-1709) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SUPT6H / SPT6 Antibody (aa1660-1709, Biotin) LS-C436699

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa1660-1709) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SUPT6H / SPT6 Antibody (aa1660-1709, FITC) LS-C436700

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa1660-1709) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• Biotin
• FITC

• Unconjugated
• Biotin
• FITC

Select

SUPT6H / SPT6 Antibody (aa538-666) LS-C315034

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa538-666) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$318; 200 µl/$364; 500 µl/$518; 1 ml/$595; 2 ml/$822; 5 ml/$1,345

Select

SUPT6H / SPT6 Antibody (aa99-127) LS-C161621

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa99-127) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

SUPT6H / SPT6 Antibody (aa1553-C-term) LS-C287659

Antibody:

SUPT6H / SPT6 Rabbit anti-Human Polyclonal (aa1553-C-term) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

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