SUFU

suppressor of fused homolog (Drosophila)

Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation.

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Products

Antibodies (23)

Proteins (6)

Type

Over-Expression Lysate (2)

Primary (23)

Recombinant (4)

Target

SUFU (29)

Reactivity

Human (23)

Mouse (18)

Rat (13)

African green monkey (1)

Bat (9)

Bovine (3)

Chicken (6)

Chimpanzee (9)

Dog (9)

Gibbon (9)

Guinea pig (9)

Horse (9)

Monkey (9)

Orangutan (3)

Pig (9)

Rabbit (9)

Xenopus (3)

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Application

IHC (7)

IHC-P (7)

WB (22)

ELISA (4)

ICC (1)

IF (4)

IP (2)

Peptide-ELISA (2)

Host

rabbit (22)

mouse (1)

Product Group

IHCPlus (2)

Isotype

IgG (7)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (22)

Clone

1783CT536.263.29 (1)

Format

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

Unconjugated (14)

Epitope

C-Terminus (4)

aa215-264 (4)

aa35-84 (4)

aa308-341 (1)

aa325-375 (1)

aa325-484 (1)

aa434-484 (1)

Publications

No (29)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Select

SUFU Antibody (C-Terminus) LS-B6811

Antibody:

SUFU Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

Select

SUFU Antibody (C-Terminus, HRP) LS-C438215

Antibody:

SUFU Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SUFU Antibody (C-Terminus, Biotin) LS-C438212

Antibody:

SUFU Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SUFU Antibody (C-Terminus, FITC) LS-C438214

Antibody:

SUFU Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

IHC-plus™ SUFU Antibody LS-B14541

(4.0) Rating

Antibody:

SUFU Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

SUFU Antibody (aa325-484) LS-C380211

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa325-484) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

Select

SUFU Antibody LS-C755271

Antibody:

SUFU Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

SUFU Antibody (clone 1783CT536.263.29) LS-C757665

Antibody:

SUFU Mouse anti-Human Monoclonal (1783CT536.263.29) Antibody

Reactivity:

Mouse, Human, African green monkey

Applications:

ELISA, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

SUFU Antibody LS-C770982

Antibody:

SUFU Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

SUFU Antibody LS-C748477

Antibody:

SUFU Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

SUFU Antibody LS-C413718

Antibody:

SUFU Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

0.1 mg/$394

Select

SUFU Antibody (aa434-484) LS-C289086

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa434-484) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

SUFU Antibody (aa308-341) LS-C392788

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa308-341) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

Select

SUFU Antibody LS-C806789

Antibody:

SUFU Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

SUFU Antibody (aa35-84) LS-C109732

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa35-84) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SUFU Antibody (aa35-84, HRP) LS-C428922

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa35-84) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SUFU Antibody (aa35-84, Biotin) LS-C428920

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa35-84) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SUFU Antibody (aa35-84, FITC) LS-C428921

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa35-84) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SUFU Antibody (aa215-264) LS-C109731

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa215-264) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

SUFU Antibody (aa215-264, HRP) LS-C428919

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody

Reactivity:

Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

SUFU Antibody (aa215-264, Biotin) LS-C428852

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody

Reactivity:

Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

SUFU Antibody (aa215-264, FITC) LS-C428918

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody

Reactivity:

Chicken, Rat, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Gibbon, Chimpanzee, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

SUFU Antibody (aa325-375) LS-C289085

Antibody:

SUFU Rabbit anti-Human Polyclonal (aa325-375) Antibody

Reactivity:

Human

Applications:

IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

Human SUFU Protein (Recombinant GST, N-terminus) (aa181-280) - LS-G62516

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human SUFU Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68711

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

53.8 kDa

Price:

20 µg/$1,107

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