Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
STXBP1 Antibody, EIEE4 Antibody, HUNC18 Antibody, MUNC18-1 Antibody, N-Sec1 Antibody, NSEC1 Antibody, Protein unc-18 homolog 1 Antibody, Protein unc-18 homolog A Antibody, UNC18 Antibody, Unc18-1 Antibody, p67 Antibody, RBSEC1 Antibody, Unc-18A Antibody, Munc18 Antibody, Neuronal SEC1 Antibody, Syntaxin binding protein 1 Antibody, Syntaxin-binding protein 1 Antibody, UNC18A Antibody
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Western blot of rat cortex lysate showing specific immunolabeling of the ~65k Munc-18 protein phosphorylated at Ser515. Immunolabeling is blocked by the phosphopeptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown).